Hepatic copper and iron accumulation and histologic findings in 104 feline liver biopsies

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Jacqueline C WhittemoreAnn Reed

Abstract

In contrast to dogs, the role of copper and iron accumulation in feline hepatic disease remains poorly characterized. Therefore, the objective of the current study was to compare the amount and distribution of copper and iron accumulation for different disease processes in feline liver biopsies. Liver biopsies (from 104 privately owned cats) were categorized by primary histopathologic lesion. Copper (by rubeanic acid) and iron (by Prussian blue) accumulation were graded by amounts (0-3) and location (centrilobular, midzonal, periportal, random). The Kruskal-Wallis test and Pearson chi-square test were used to assess differences in metal grade and location, respectively, between diagnostic categories. Histologic diagnoses were normal (n = 12), congenital (n = 6), neoplastic (n = 16), infectious and/or inflammatory (n = 39), and other (n = 31). Hepatocellular iron staining was negative in 18 samples; remaining samples had grade 1 (n = 38), 2 (n = 40), and 3 (n = 8) accumulation. Ninety-two samples were negative for copper; remaining samples had grade 1 (n = 5), 2 (n = 6), and 3 (n = 1) accumulation. No significant differences were found in the amount of iron or copper accumulation between the different diagnostic categories. Diag...Continue Reading

References

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Citations

Dec 19, 2013·Journal of the American Veterinary Medical Association·Brandi M HurwitzJason Pintar
May 3, 2014·Veterinary Pathology·J M BernardE C Ramsay
Nov 7, 2019·Journal of Feline Medicine and Surgery·Hajime AsadaKoichi Ohno
Oct 8, 2020·Journal of Feline Medicine and Surgery·Punyamanee YamkateJonathan A Lidbury
Jan 16, 2021·Veterinary Clinical Pathology·Carol E Haak, Julie L Webb
Jan 12, 2021·Oxidative Medicine and Cellular Longevity·Qiuyuan YangShuguang Chen
Mar 7, 2021·Animals : an Open Access Journal From MDPI·Ronald Jan Corbee, Louis C Penning

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Methods Mentioned

BETA
biopsy
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