PMID: 6978230Jan 1, 1982Paper

Hepatic cytochrome P-450-dependent monooxygenase systems of the trout, frog and snake--III. Induction

Comparative Biochemistry and Physiology. B, Comparative Biochemistry
R J Schwen, G J Mannering

Abstract

1. 3-Methylcholanthrene administration increased levels of cytochrome P-450, benzo[a]pyrene hydroxylase activity and p-nitrophenetole O-deethylase activity in hepatic microsomes from the brown trout (Salmo trutta), leopard frog (Rana pipiens) and the garter snake (Thamnophis). The level of aminopyrine N-demethylase activity was increased in trout microsomes, but not in those from the frog, snake or rat. 2. The shift in the Soret maximum of the reduced carbon monoxide difference spectrum of cytochrome P-450 from 450 to 448 nm, which is observed when 3-methylcholanthrene is administered to rats, was not seen in microsomes from the trout, frog or snake. 3. Benzo[a]pyrene hydroxylase activity induced by 3-methylcholanthrene in the trout, frog and snake was inhibited by relatively low concentrations of SKF 525-A, but that induced in the rat was not. alpha-Naphthoflavone inhibited 3-methylcholanthrene-induced benzo[a]pyrene hydroxylase activity in the trout, frog and rat, but not in the snake. 4. 3-Methylcholanthrene induced an increase in the 455/430 nm peak height ratio of the reduced ethylisocyanide spectrum of microsomes in the rat and trout, but not in the frog or snake. 5. These observations (items 1--4 of the abstract) show th...Continue Reading

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Jan 1, 1982·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R J Schwen, G J Mannering
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Citations

Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J L RivièreJ Bach
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J C BastosM V Faria
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