Hepatic Damage by Natural Remedies

Seminars in Liver Disease
Raul J AndradeM Isabel Lucena

Abstract

The rising burden of herbal and dietary supplement hepatotoxicity (HILI) is a growing concern in Western countries. The estimated incidence of HILI in well-designed prospective studies ranges from less than 1 to 3 individuals per 100,000 inhabitants/year. Herbal hepatotoxicity has a particular signature encompassing female predominance, hepatocellular type of damage with markedly elevated transaminases on presentation, more common unintentional rechallenge, and a greater risk of death/liver transplantation. Herbal hepatotoxicity recognition is particularly challenging for hepatologists because of the often hidden herbal consumption, difficulties in identifying the causative herbal component, and the possibility of contamination, adulteration, and misidentification, which preclude a proper adjudication and lead to inaccurate reporting of cases in scientific journals. Collaborative efforts to retrieve detailed phenotypic data and biological samples of patients with HILI would facilitate genomic and other molecular approaches for a better understanding of host risk factors and, hopefully, for biomarker identification.

Citations

Jan 30, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Raúl J Andrade
Aug 24, 2019·Nature Reviews. Disease Primers·Raul J AndradeGuruprasad P Aithal
Jun 27, 2020·Frontline Gastroenterology·Nelia HernandezFernando Bessone
Oct 3, 2020·Clinical Liver Disease·Vinicius Nunes, Nahum Mendez-Sanchez
Jan 13, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Fernando BessoneRaúl J Andrade
Feb 17, 2021·Nature Reviews. Gastroenterology & Hepatology·Jordi Gracia-SanchoRubén Francés
Jun 22, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Martin Reike-KunzeMarcial Sebode
Jul 14, 2021·Expert Opinion on Drug Safety·Miren García-CortésRaúl J Andrade
Sep 10, 2021·Journal of Evidence-based Integrative Medicine·Pei Lin LuaFarrahdilla Hamzah
Sep 24, 2021·Annals of Hepatology·Pedro Felipe SoaresRaymundo Paraná

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