PMID: 3770258Jan 1, 1986Paper

Hepatic disease in erythropoietic protoporphyria

Dermatologica
B R MooyaartC H Gips

Abstract

A standardized hepatological investigation was performed in 9 unselected patients with erythropoietic protoporphyria (EPP). The aim of this study was to detect early liver involvement due to EPP and to determine the significance of several diagnostic procedures. Scintigraphy revealed slight enlargement of liver and spleen in all cases. Light microscopic examination of liver tissue in 7 patients showed protoporphyrin deposition in 4 and signs of fibrosis in 3 cases. Cirrhosis was not found. Electron microscopical examination (EM) of all 7 cases was negative and needle-shaped crystals were not found. Therefore we regard EM of little diagnostic value in the detection of early liver involvement. The literature on fatal and asymptomatic cases of liver involvement in EPP is discussed with emphasis on possible predictive and provocative factors. A proposal for EPP patients intending to reduce possible risk factors is made.

Citations

Jun 1, 1989·Clinical Biochemistry·M O Doss, M Frank
Feb 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·P Williams-AryaN W Wilson
Sep 22, 2010·World Journal of Gastroenterology : WJG·María José Casanova-GonzálezRicardo Moreno-Otero
Nov 1, 1993·Journal of the American Academy of Dermatology·M G MercurioD R Bickers
Sep 1, 1992·Journal of Hepatology·Y Nordmann
Feb 1, 1994·Annals of Medicine·R KauppinenP Mustajoki
May 15, 1996·Transplantation·I de TorresP S Randhawa
May 1, 1991·Clinical and Experimental Dermatology·S A ShehadeR J Prescott
Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J R Bloomer
Aug 31, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Zaid S ArdalanPaul J Gow
Sep 1, 1990·Journal of Gastroenterology and Hepatology·J M RankJ R Bloomer
Dec 1, 1994·The British Journal of Dermatology·D J Todd
May 1, 1996·The British Journal of Dermatology·G GoerzN Y Schürer
Sep 30, 2000·Clinical and Experimental Dermatology·G K PatelJ L Hawk
Sep 4, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Debby WensinkJanneke G Langendonk

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