PMID: 18181321Jan 10, 2008Paper

Hepatic dysfunction in pediatric scrub typhus: role of liver function test in diagnosis and marker of disease severity

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Chulapong ChantaWarangkana Mahaprom

Abstract

Determine the frequency of abnormalities of liver function test in children with scrub typhus and its relation with severity of disease. Fifty-four children diagnosed with scrub typhus at Chiang Rai Regional Hospitalfrom January 2004 to December 2005 were studied. The diagnosis of scrub typhus in the present study was based on a single indirect immunofluorescent antibody (IFA) titer against O tsutsugamushi of > or = 1:400 or a four fold or greater rise in IFA titer to at least 1:200. Liver function tests (LFT) were done on the first few days of admission in all patients. Abnormalities of LFT were focused on serum AST, ALT albumin and total bilirubin level. All of the patients were divided into two groups based on the presence or absence of complications. Fifty-two patients (96.3%) had abnormal LFT. Evaluation of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were detected in 52 (96.3%) and 36 (66.7%) cases, respectively. Hypoalbuminemia and hyperbilirubinemia were detected in 23 (42.6%) and 4 (7.4%) cases, respectively. The higher level of AST, ALT and lower level ofserum albumin correlated significantly with the severity of scrub typhus in children. Hepatic dysfunction is common in children with scrub typh...Continue Reading

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