Hepatic elastin content is predictive of adverse outcome in advanced fibrotic liver disease

Histopathology
Timothy J KendallIndra N Guha

Abstract

The aim of this study was to determine if elastin content in needle core native liver biopsies was predictive of clinical outcome in patients with chronic hepatitis C virus-related chronic liver disease. Elastin contents in liver biopsies were determined by image analysis, technically validated in an independent centre, and correlated with outcome in patients with advanced (Ishak stage ≥5) chronic hepatitis C virus-related chronic liver disease. Elastin was robustly quantified in an operator-independent and laboratory-independent manner, with very strong correlation of elastin staining measured with two methods of image classification (rs = 0.873, P < 0.00001). Elastin content (but not absolute scar content or Ishak stage) was predictive for future clinical outcomes. In a cohort of patients without sustained virological response, the median hepatic elastin content was 3.4%, and 17 patients (57%) progressed to a liver-related clinical outcome; 11 of the 15 patients (73%) with a hepatic elastin content of >3.4% progressed to a clinical outcome, as compared with only six of 15 (40%) with an elastin content of <3.4%. The difference in time to outcome was significant. We describe a simple and reproducible method for elastin quantifi...Continue Reading

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Citations

May 27, 2020·Obesity Surgery·Carine LeiteCarlos Thadeu Schmidt Cerski
Dec 3, 2020·Frontiers in Immunology·Claire E McQuittyLuca Urbani
Jul 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Michitaka Matsuda, Ekihiro Seki
Jun 3, 2021·The Journal of Pathology. Clinical Research·Stuart AstburyTimothy J Kendall

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biopsy
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spss statistics
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