Hepatic encephalopathy: a neurochemical, neuroanatomical, and neuropsychological study

Journal of Applied Clinical Medical Physics
Nader BineshFawzy Fawzy

Abstract

Hepatic encephalopathy (HE) is normally diagnosed by neuropsychological (NP) tests, which are not very specific and do not reveal the underlying pathology. Magnetic resonance imaging (MRI) and spectroscopy (MRS) of the brain offer alternative and possibly more specific markers for HE. These methods were applied in conjunction with NP testing in order to determine their usefulness in the identification of HE and to understand the pathogenesis of HE more clearly. MR imaging and spectroscopy examinations, in addition to a battery of 15 NP tests, were administered to investigate 31 patients awaiting liver transplantation and 23 healthy controls. MR image intensities from the globus pallidus region were calculated and normalized to those of the thalamus. Absolute concentrations and ratios with respect to creatine (Cr) of several metabolites were computed from MR spectra. The MR data were correlated with the results of NP tests. The patients showed impairment in NP tests of attention and visuospatial and verbal fluency. In T1-weighted MRI, the relative intensity of the globus pallidus with respect to that of the thalamus region was significantly elevated in patients and correlated(negatively) with three NP tests (Hooper, FAS, and Tra...Continue Reading

References

Dec 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J KulisevskyC Villanueva
Jan 1, 1989·The Journal of Surgical Research·A W BoddieL Dennis
Dec 1, 1989·Investigative Radiology·J D Glickson
Oct 3, 1985·The New England Journal of Medicine·C L Fraser, A I Arieff
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P BernthalA Hegedus
Dec 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S W Provencher
Jul 1, 1993·Radiology·J H DuynC T Moonen
May 1, 1996·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·R A HauserC W Olanow
Jan 1, 1996·Digestive Diseases·A T Blei, J Cordoba
Oct 8, 1998·AJR. American Journal of Roentgenology·M A ThomasF Fawzy
Feb 12, 1999·Metabolic Brain Disease·G P LayrarguesR F Butterworth
Mar 17, 2001·Stereotactic and Functional Neurosurgery·K N FountasN Papadakis
Jul 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M A ThomasB Guze
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peter FerenciAndres T Blei
May 22, 2003·The International Journal of Biochemistry & Cell Biology·Rajiv JalanNathan Davies

❮ Previous
Next ❯

Citations

Jul 10, 2007·Intensive Care Medicine·Sophie De RoockThierry Duprez
Jun 24, 2011·Metabolic Brain Disease·Manoj K SarmaM Albert Thomas
Jun 11, 2009·AJNR. American Journal of Neuroradiology·B R FoersterK B Schwarz
Apr 22, 2014·Seminars in Ultrasound, CT, and MR·Juli AlonsoAlex Rovira
Feb 11, 2012·Clinics in Liver Disease·Mark J W McPhailSimon D Taylor-Robinson
Oct 27, 2009·Journal of Magnetic Resonance Imaging : JMRI·Aparna SinghalM Albert Thomas
Mar 24, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Christopher RandolphUNKNOWN International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN)
Oct 28, 2014·Brain Pathology·Natalie M ZahrAdolf Pfefferbaum
Jun 28, 2011·Journal of Hepatology·Bruno OzannePhilippe Jouvet
Oct 6, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Hannelore RingeUwe Querfeld
Sep 20, 2012·Journal of Environmental and Public Health·Sam De Coster, Nicolas van Larebeke
Jan 1, 2008·Magnetic Resonance Insights·A HudaM A Thomas
Mar 12, 2010·Metabolic Brain Disease·Mark J W McPhail, Simon D Taylor-Robinson
Apr 23, 2019·Journal of Neuroscience Research·Michael FritzNatalie M Zahr
Jun 14, 2019·Addictive Behaviors Reports·Arkadiy L MaksimovskiyRegina E McGlinchey
Jan 21, 2021·International Journal of Molecular Sciences·So Yeong Cheon, Juhyun Song
May 22, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Chathur Acharya, Jasmohan S Bajaj

❮ Previous
Next ❯

Software Mentioned

LCModel

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
William BernalJulia Wendon
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
J O ClemmesenPeter Ott
© 2021 Meta ULC. All rights reserved