Hepatic endothelial cells. Targets in liver allograft rejection?

Transplantation
D H AdamsJ Neuberger

Abstract

Hepatic endothelial cell damage was evaluated in patients following liver transplantation using 2 serum markers: hyaluronic acid (HA), which measures hepatic endothelial cell function, and factor VIII related antigen (VIIIRAg), an indicator of generalized endothelial damage. HA was elevated in rejection (median 22.3 x control) when compared with stable patients (3.7 x control; P less than 0.00001) and those with posttransplant complications not related to rejection (6.8 x control; P less than 0.0005). The highest levels were seen in patients with chronic rejection (28.7 x control). Levels were also elevated in acute rejection (21.3 x control), and the highest levels in this group were seen in patients who subsequently developed chronic rejection (25.2 x control). Serial studies demonstrated that HA increased 24 hr before serum bilirubin in patients developing acute rejection. VIIIRAg was elevated in all posttransplant patients with no significant difference between rejection and other complications. These results show that hepatic endothelial dysfunction occurs during acute and particularly chronic rejection of liver allografts suggesting that VECs may be an important target of the immune response. Measurement of HA may allow f...Continue Reading

Citations

Sep 9, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R H WiesnerR A Krom
Sep 15, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·U LindqvistK Hellsing
Jul 1, 1991·Immunology Letters·D Adams
Jan 1, 1989·Current Opinion in Immunology·N V Jamieson
Nov 25, 2000·Clinical Transplantation·A ShimizuN Yamanaka
Sep 1, 1999·European Journal of Clinical Investigation·T OgataS Aoyagi
Jul 25, 2000·European Journal of Clinical Investigation·U LindqvistB Långström
Oct 1, 1996·European Journal of Clinical Investigation·E SchützM Oellerich
Jan 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·M R SchönP Neuhaus
Jan 1, 1995·Journal of Gastroenterology and Hepatology·B Smedsrød
Apr 1, 1996·Journal of Gastroenterology·K SuzukiS Sato
Oct 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Suchitra Sumitran-HolgerssonBo-Göran Ericzon
Mar 26, 2003·Liver International : Official Journal of the International Association for the Study of the Liver·Anna M WilliamsRobin D Hughes
Feb 7, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Kojiro NakamuraShinji Uemoto
May 14, 1998·The Journal of Laboratory and Clinical Medicine·K N LaiJ C Leung
Jan 1, 1990·Journal of Hepatology·D H Adams, J M Neuberger
Mar 1, 1991·Journal of Hepatology·G Paintaud, J P Miguet
Apr 1, 1993·Journal of Hepatology·J DevlinR Williams
Feb 7, 1998·The Journal of Surgical Research·T SuehiroC M Miller
Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W J SandbornR H Wiesner
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H ShimizuR E Falk
Feb 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I V DeaciucJ J Spitzer
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T IkedaK Sugimachi
Jun 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P R GibsonF J Dudley
Oct 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H WiesnerR A Krom
Dec 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G W McCaughanD M Painter
Apr 25, 2001·The American Journal of Gastroenterology·M E García-JiménezV Carreño
Jun 4, 1998·Circulation·S A Hunt, O H Frazier
Oct 22, 2005·Journal of Internal Medicine·J R E Fraser, P R Gibson
Jun 1, 1996·Annals of Medicine·T C LaurentJ R Fraser

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