Hepatic enzyme induction and mutagenicity of airborne particulate matter from Santiago, Chile in the nourished and malnourished rat

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
M AdonisG Gibson

Abstract

1. Respirable, airborne particles in the ambient air in downtown Santiago, Chile, have been characterized for the seasonal variation in total polycyclic aromatic hydrocarbon content, 13 of which have been identified including the mutagens (benzo(a)pyrene, dibenzo(a,h)anthracene, benzo(a)anthracene, benzo(b)fluoranthene and indeno(1,2,3, c,d)pyrene amongst others. 2. Organic extracts derived from these particles were administered to both the nourished and malnourished rat and resulted in modulation of the hepatic mixed function oxidase system including induction of NADPH-cytochrome P450 reductase, cytochrome P4501A as determined by Western blot analysis and the associated ethoxyresorufin O-deethylase and aryl hydrocarbon hydroxylase activities. 3. The cytochrome P4504A1-dependent 12-hydroxylation of lauric acid was induced in the malnourished state, but this activity was significantly inhibited by treatment of the animals with particle extracts in both nutritional states. 4. The particle extracts contained both direct and indirect-acting mutagens in the Ames test, and depending on the relative complement of both, resulted in either increased or decreased mutagenicity in the presence of S9 activation systems derived from both nou...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M GöttlicherJ A Gustafsson
Nov 1, 1992·Environmental Health Perspectives·F PereraG Motykiewicz
Apr 1, 1983·Journal of Toxicology and Environmental Health·I SalazarL Gil
Jan 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L Quiñones, L Gil
Jan 1, 1993·Drug Metabolism Reviews·C Ioannides, D V Parke

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