Hepatic fibrosis: evaluation with semiquantitative contrast-enhanced CT

Radiology
Vanja VarenikaBenjamin M Yeh

Abstract

To evaluate the feasibility of using contrast material-enhanced computed tomographic (CT) measurements of hepatic fractional extracellular space (fECS) and macromolecular contrast material (MMCM) uptake to measure severity of liver fibrosis. All procedures were approved by and executed in accordance with University of California, San Francisco, institutional animal care and use committee regulations. Twenty-one rats that received intragastric CCl(4) for 0-12 weeks were imaged with respiratory-gated micro-CT by using both a conventional contrast material and a novel iodinated MMCM. Histopathologic hepatic fibrosis was graded qualitatively by using the Ishak fibrosis score and quantitatively by using morphometry of the fibrosis area. Hepatic fECS and MMCM uptake were calculated for each examination and correlated with histopathologic findings by using uni- and multivariate linear regressions. Ishak fibrosis scores ranged from a baseline of 0 in untreated animals to a maximum of 5. Histopathologic liver fibrosis area increased from 0.46% to 3.5% over the same interval. Strong correlations were seen between conventional contrast-enhanced CT measurements of fECS and both the Ishak fibrosis scores (R(2) = 0.751, P < .001) and the fib...Continue Reading

References

Dec 1, 1988·The Journal of Clinical Investigation·J ReichenA Zimmermann
Feb 1, 1988·Alcoholism, Clinical and Experimental Research·P BedossaJ C Chaput
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
May 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D M ShamesR C Brasch
Jan 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J P VilleneuveD Marleau
Jun 1, 1996·Gastrointestinal Endoscopy·J PoniachikE R Schiff
Aug 3, 1999·AJR. American Journal of Roentgenology·T KimH Nakamura
Jan 25, 2000·The Journal of Biological Chemistry·S L Friedman
Oct 6, 2000·The Journal of Physiology·S Sahin, M Rowland
Jan 4, 2003·Gastroenterology·Jules L DienstagEugene R Schiff
Mar 26, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bernard E Van BeersYves Horsmans
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thierry PoynardJanice Albrecht
Jun 8, 2004·The American Journal of Gastroenterology·Nezam H Afdhal, David Nunes
Jun 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·John B DixonPaul E O'Brien
Jan 24, 2006·Journal of Hepatology·Julie ParkesWilliam Rosenberg
Mar 9, 2006·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Eleni L TolmaJohn Ureda
May 16, 2006·Digestive Diseases·Andrew J Fowell, John P Iredale
Jul 26, 2006·Radiology·Olivier RouvièreRichard L Ehman
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ludivine FalizeYves Deugnier
Feb 22, 2007·AJR. American Journal of Roentgenology·Mireen Friedrich-RustChristoph Sarrazin
May 13, 2008·Gastroenterology·Scott L Friedman
Sep 17, 2008·Annals of Internal Medicine·Vincent MalletStanislas Pol
Apr 22, 2009·AJR. American Journal of Roentgenology·Giuseppe BrancatelliKaren Pealer
Sep 12, 2009·Journal of Clinical Gastroenterology·Justin StebbingMark Nelson
Apr 7, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Leonard B SeeffUNKNOWN HALT–C Trial Group
Apr 19, 2011·Best Practice & Research. Clinical Gastroenterology·Ursula E Lee, Scott L Friedman
Jun 24, 2011·The New England Journal of Medicine·Ira M JacobsonUNKNOWN ADVANCE Study Team

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Citations

May 9, 2014·Journal of Digital Imaging·Hannu T HuhdanpaaGrace L Su
Nov 20, 2015·Frontiers in Pharmacology·Jeffrey R AshtonCristian T Badea
Aug 13, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Yasutaka YamadaYuzo Kodama
Aug 31, 2018·Current Gastroenterology Reports·Rishi Philip Mathew, Sudhakar Kundapur Venkatesh
Aug 11, 2020·Abdominal Radiology·Khaled Y ElbannaLuís S Guimarães
Jul 18, 2015·World Journal of Gastroenterology : WJG·Xiang-Wei HuaQiang Xia
Aug 25, 2015·World Journal of Hepatology·Suk Keu YeomCheol Min Park
Dec 17, 2016·Journal of Magnetic Resonance Imaging : JMRI·Léonie PetitclercAn Tang
Nov 20, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Irene Marco-RiusMatthew Merritt
Jan 28, 2021·Diagnostics·Masakatsu TsurusakiMasatoshi Kudo
Feb 23, 2021·European Journal of Radiology·Jeong Hee YoonKyung-Suk Suh

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