Hepatic glutathione biosynthetic capacity in hyperthyroid rats

Toxicology Letters
Virginia Fernández, Luis A Videla

Abstract

The influence of hyperthyroidism on the capacity of the liver to synthesize glutathione (GSH) was evaluated as a possible mechanism of depletion of the tripeptide. For this purpose, the effect of daily doses of 0.1 mg 3, 3',5-tri-iodothyronine (T3)/kg for 3 consecutive days on hepatic GSH biosynthetic capacity was assessed by a combined assay measuring gamma-glutamylcysteinyl synthase and GSH synthase simultaneously. T3 treatment induced a significant 56% depletion of liver GSH in parallel with an increase in the rate of GSH synthesis, the latter effect being completely abolished by L-buthionine sulfoximine. According to these data, the fractional rate of hepatic GSH turnover exhibited a 3.2-fold enhancement in hyperthyroid rats compared to control animals. It is concluded that the enhanced GSH utilization in the liver of hyperthyroid rats previously observed [Fernández et al., Endocrinology 129, 85-91, 1991], is accompanied by an increment in GSH synthesis that is insufficient to sustain the basal levels of the tripeptide observed in euthyroid animals, thus establishing a low steady-state content of GSH in the tissue.

References

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Citations

Feb 9, 2012·International Journal of Endocrinology·Dipak K Sahoo, Anita Roy
Sep 6, 2015·European Journal of Endocrinology·Ihsan AtesSerdar Güler
Jan 6, 2001·Redox Report : Communications in Free Radical Research·L A Videla
Feb 9, 2006·Life Sciences·Rasim MogulkocAbdullah Sivrikaya
Jun 15, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·S ChattopadhyayG B N Chainy
Nov 2, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Anna Cleta CroceGiovanni Bottiroli
Nov 22, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Virginia FernándezLuis A Videla
Aug 8, 2021·International Journal of Environmental Research and Public Health·Joanna SzczepanikKatarzyna Domaszewska
Dec 21, 2007·General and Comparative Endocrinology·Dipak K SahooGagan B N Chainy
Nov 17, 2009·Chemico-biological Interactions·Umakanta Subudhi, Gagan B N Chainy
Aug 4, 2010·General and Comparative Endocrinology·Sutapa ChattopadhyayLuna Samanta

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