Hepatic glycogenosis: An underdiagnosed complication of diabetes mellitus?

World Journal of Diabetes
María Teresa JuliánManel Puig-Domingo

Abstract

Hepatic glycogenosis (HG) is characterized by excessive glycogen accumulation in hepatocytes and represents a hepatic complication of diabetes that particularly occurs in patients with longstanding poorly controlled type 1 diabetes (T1D). HG has been reported to be a very rare disease, although it is believed to be extremely underdiagnosed because it is not possible to distinguish it from non-alcoholic fatty liver disease (NAFLD) unless a liver biopsy is performed. In contrast to HG, NAFLD is characterized by liver fat accumulation and is the more likely diagnosis for patients with type 2 diabetes and metabolic syndrome. The pathogenesis of HG involves the concomitant presence of insulin and excess glucose, which increases glycogen storage in the liver. HG is characterized by a transient elevation in liver transaminases and hepatomegaly. Differentiating between these two conditions is of the utmost importance because HG is a benign disease that is potentially reversible by improving glycemic control, whereas NAFLD can progress to cirrhosis. Therefore, HG should be suspected when liver dysfunction occurs in patients with poorly controlled T1D. The aim of this article is to review the epidemiology, clinical characteristics, patho...Continue Reading

Citations

Feb 24, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Marco SilvaGuilherme Macedo
Dec 10, 2015·Journal of Cellular and Molecular Medicine·Ying WanFanyin Meng
Apr 3, 2016·Free Radical Biology & Medicine·Preeti Kanikarla-Marie, Sushil K Jain
Sep 25, 2017·Journal of Computer Assisted Tomography·Tetiana GlushkoOleg M Teytelboym
Jan 9, 2019·Italian Journal of Pediatrics·Fortunato LombardoGiuseppina Salzano
Jan 23, 2021·Clinical Medicine : Journal of the Royal College of Physicians of London·Amera ElzubeirJames Sington
Feb 18, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Samir HaffarFateh Bazerbachi
Sep 29, 2019·GE Portuguese Journal of Gastroenterology·Marta PatitaJorge Fonseca

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