PMID: 9656120Jul 10, 1998Paper

Hepatic (hepatocellular) adenoma of the placenta: a study of four cases

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
M A KhalifaJ M Lage

Abstract

Hepatic (hepatocellular) adenoma of the placenta is an extremely rare nontrophoblastic placental lesion of disputed histogenesis, four examples of which were diagnosed over a 10-year period. The lesions, which were incidental findings in women 21 to 30 years of age (mean, 25; median, 24.5), ranged from 0.3 to 1.0 cm in greatest dimension. Two were found within the villous parenchyma and two in subchronic locations. On cross section, two examples were tan to dark red nodules without necrosis or hemorrhagic foci, whereas two were not visible grossly. The lesions were composed of semidistinct lobules of cords and nests of polygonal epithelial cells resembling fetal liver. Extramedullary hematopoiesis was a constant feature. The lesional cells contained glycogen and were immunoreactive for cytokeratin, alpha-fetoprotein, alpha-1-antitrypsin, and carcinoembryonic antigen. Although the histogenesis of these lesions remains uncertain, an origin from displaced yolk sac elements with hepatocytic differentiation is the most likely hypothesis. It is important to distinguish hepatic adenoma of the placenta from placental cell island, heterotopic adrenocortical nodule, chorangioma, and placental metastasis of maternal and fetal malignancies.

Citations

Sep 27, 2000·Obstetrics and Gynecology·J L BarthaJ Arrabal
Sep 24, 2004·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Taka-Aki MatsuyamaHidekazu Ota
Jul 18, 2015·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Thomas Scott DeNapoli
Nov 26, 2015·Seminars in Diagnostic Pathology·Evelyn T Bruner
Jan 3, 2014·Case Reports in Pathology·Hua ZhongDorota A Popiolek
Jun 7, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Drucilla J Roberts, Esther Oliva
Jun 9, 2017·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Rasleen SalujaDebra S Heller
Sep 25, 2018·Journal of Medical Primatology·Natalia Schlabritz-LoutsevitchJerzy Stanek
Jun 15, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·David P StonkoAlexandra E Kovach
Jul 23, 2020·Fetal and Pediatric Pathology·Nora Schaumann, Kais Hussein
Sep 30, 2020·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Amy Heerema-McKenneyHalit Pinar
Mar 17, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Monique E De PaepeFrancois I Luks
Apr 24, 2016·International Journal of Surgical Pathology·Eric U YeeDouglas I Lin
Jan 6, 2021·Fetal and Pediatric Pathology·Saman S Karimi, Steven Garzon
Apr 4, 2008·Archives of Pathology & Laboratory Medicine·Drucilla J Roberts
Oct 5, 2021·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Stacy D WebbDebra S Heller
Nov 12, 2021·International Journal of Surgical Pathology·Johann Sebastián Ospina-SerranoMercedes Olaya-C

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