PMID: 9543347Jun 6, 1998Paper

Hepatic heterogeneity in the response to ATP studied in the bivascularly perfused rat liver

Molecular and Cellular Biochemistry
V C Minguetti-CâmaraAdelar Bracht

Abstract

The zonation of the purinergic action of ATP in the hepatic parenchyma was investigated in the bivascularly perfused rat liver by means of anterograde and retrograde perfusion. Livers from fed rats were used, and ATP was infused according to four different experimental protocols: (A) anterograde perfusion and ATP infusion via the portal vein; (B) anterograde perfusion and ATP via the hepatic artery; (C) retrograde perfusion and ATP via the hepatic vein; (D) retrograde perfusion and ATP via the hepatic artery. The following metabolic parameters were measured: glucose release, lactate production and oxygen consumption. The hemodynamic effects were evaluated by measuring the sinusoidal mean transit times by means of the indicator-dilution technique. ATP was infused during 20 min at four different rates (between 0.06-0.77 micromol min[-1] g liver[-1]; 20-200 microM) in each of the four experimental protocols. The results that were obtained allow several conclusions with respect to the localization of the effects of ATP along the hepatic acini: (1) In retrograde perfusion the sinusoidal mean transit times were approximately twice those observed in anterograde perfusion. ATP increased the sinusoidal mean transit times only in retrogr...Continue Reading

Citations

Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Ana RamírezJavier Camacho
May 28, 2005·Cell Biochemistry and Function·Daniele GimenesAdelar Bracht
Jun 11, 1999·The American Journal of Physiology·R M RomanJ G Fitz
Jan 8, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Talma R L FernandesAdelar Bracht
Aug 11, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jurandir Fernando ComarAdelar Bracht
Nov 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daniel S EmmettJ Gregory Fitz
Sep 12, 2007·Molecular and Cellular Biochemistry·Ana Carla Broetto-BiazonAdelar Bracht
Jul 29, 1999·Biochemical Pharmacology·T R FernandesA Bracht
May 10, 2005·Regulatory Peptides·Angelita Polato SchmeischAdelar Bracht

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