Hepatic imaging with iodinated nanoparticles: a comparison with iohexol in rabbits

Academic Radiology
G S GazelleJ L Toner

Abstract

We evaluated the efficacy of a particulate computed tomography (CT) contrast agent in an animal model of focal liver disease. Ethyl ester of diatrizoic acid (EEDA) is an iodinated (89 mg I/ml) nanoparticulate (200 nm) contrast agent intended for intravenous use that is currently undergoing preclinical testing in our laboratory. Focal liver abscesses were created in 11 New Zealand White rabbits. Iohexol and EEDA were administered to each animal on different days. CT scanning was performed at intervals following contrast agent administration. Liver and abscess enhancement were measured and compared. Dynamic imaging experiments in normal animals were also performed using both agents. EEDA resulted in significantly greater enhancement of the liver and liver-to-abscess contrast than did iohexol at all time points beyond 5 min at approximately 25% of the total iodine load. During dynamic imaging, liver and aortic enhancement were greater with EEDA than with iohexol, except during a 20- to 40-sec period immediately following contrast agent administration. EEDA is superior to iohexol for imaging liver abscesses. Our results suggest that liver-directed agents such as EEDA may prove to be more efficacious than currently available extrace...Continue Reading

References

Nov 1, 1991·Investigative Radiology·W KrauseG Rössling
Nov 1, 1991·Investigative Radiology·R F Mattrey
Feb 1, 1989·AJR. American Journal of Roentgenology·R F Mattrey
Apr 1, 1989·Radiology·S E Seltzer
Feb 1, 1989·AJR. American Journal of Roentgenology·W D Foley
Mar 1, 1989·Radiology·W D Foley
Aug 1, 1984·AJR. American Journal of Roentgenology·D L MillerM Willis
Sep 1, 1984·AJR. American Journal of Roentgenology·S E SeltzerM E Bosworth
Nov 1, 1980·Investigative Radiology·M R ViolanteJ A Mahoney

❮ Previous
Next ❯

Citations

Oct 7, 2010·Analytical and Bioanalytical Chemistry·Megan A HahnBrij M Moudgil
Aug 3, 2014·Advanced Drug Delivery Reviews·Xiang LiThierry Vandamme
Dec 7, 2011·Contrast Media & Molecular Imaging·Sungsook AhnSang Joon Lee
Oct 3, 2003·Journal of Cellular Biochemistry·Francis G Blankenberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.