Hepatic inflammation and insulin resistance in pre-diabetes - further evidence for the beneficial actions of PPAR-gamma agonists and a role for SOCS-3 modulation.

British Journal of Pharmacology
Prabal K Chatterjee

Abstract

Pre-diabetes is a condition affecting increasing numbers of the population who find themselves caught in the grey area between normal glucose regulation and diabetes mellitus and who experience impaired glucose tolerance or fasting glucose. The ability of thiozolidinediones (TZDs) to ameliorate the clinical signs of diabetes mellitus is well-known but there is also emerging evidence for the benefits of PPAR-gamma agonists in pre-diabetes. In this issue of the British Journal of Pharmacology, Collino and colleagues report that pioglitazone can reduce hepatic inflammation and insulin resistance in rats administered a high cholesterol and fructose diet. Furthermore, pioglitazone reduced the expression of suppressor of cytokine signalling (SOCS)-3 - considered to be a key link between inflammation and insulin resistance. Although much work remains to be performed in fully understanding how TZDs modulate the cellular mechanisms which underlie pre-diabetes, these findings provide preliminary evidence that administration of TZDs to pre-diabetics could be beneficial.

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Citations

Jan 22, 2013·Cell Biochemistry and Function·Dariusz SuchyBogusław Okopień
Aug 16, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H M KimC H Chung
Oct 28, 2017·Journal of Cellular and Molecular Medicine·Yali ZhangGuang Liang
Nov 22, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ting-Chen ChangCheng Huang
Jul 23, 2021·The Journal of Investigative Dermatology·Alvaro Gonzalez-CanteroNehal N Mehta

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