Hepatic inflammation following 70% hepatectomy may be related to up-regulation of epithelial neutrophil activating protein-78

Shock
L M CollettiR M Strieter

Abstract

Tumor necrosis factor-alpha (TNF) is known to be released after partial hepatectomy. Furthermore, TNF triggers the release of chemotactic cytokines, such as epithelial neutrophil activating protein (ENA-78), which are important for neutrophil chemotaxis, activation, and propagation of the inflammatory response. We now postulate that ENA-78 may play a role the hepatic inflammatory response that occurs following partial hepatectomy. Rats were subjected to 70% hepatectomy or sham laparotomy and were killed in a time-dependent manner. Hepatic neutrophil influx, as assessed by myeloperoxidase (MPO) levels, serum alanine aminotransferase (ALT), and hepatic TNF and ENA-78 levels, as measured by ELISA, were evaluated at 1, 6, and 12 h following operation. MPO levels became significantly elevated within 6 h of hepatectomy and remained elevated at 12 h. Serum ALT became significantly elevated within 1 h of hepatectomy and continued to rise at 12 h. Hepatic TNF and ENA-78 were also increased significantly after hepatectomy. Next, rats undergoing 70% hepatectomy were treated with neutralizing anti-ENA-78 serum; this resulted in a significant decrease in hepatic MPO and serum ALT, suggesting less hepatic injury. To determine whether ENA-78 ...Continue Reading

Citations

Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J A LawsonH Jaeschke
Feb 7, 1998·Journal of Hepatology·K J SimpsonS L Kunkel
Jul 29, 1999·Chest·R M StrieterT J Standiford
Feb 22, 2011·Cytokine & Growth Factor Reviews·Christopher J HorrasKristen A Mitchell
Aug 31, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eric W OlleLisa M Colletti
Nov 5, 2003·The Journal of Clinical Investigation·Xiaodan RenLisa Colletti
Dec 14, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Padmam PuneetMadhav Bhatia
Aug 27, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C M HogaboamS L Kunkel
May 12, 1998·The American Journal of Physiology·J G ChosayH Jaeschke

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