Hepatic inflammatory cytokine mRNA expression in hepatitis C virus-human immunodeficiency virus co-infection

Journal of Viral Hepatitis
Stevan A GonzalezAndrew H Talal

Abstract

Although epidemiologic studies have documented that hepatitis C virus (HCV)/human immunodeficiency virus (HIV) co-infected patients have accelerated fibrogenesis, especially those with CD4+ cell counts <200 cells/mm(3), the pathogenic mechanisms are poorly understood. We investigated whether severe immunodeficiency in co-infection is associated with changes in intrahepatic inflammatory cytokine mRNA levels. We measured interferon (IFN)-gamma, tumour necrosis factor-alpha, transforming growth factor (TGF)-beta(1), interleukin (IL)-4, IL-10, IL-12p35 and IL-12p40 mRNA levels by real-time PCR performed on liver samples from HCV mono-infected (n = 19) and HCV/HIV co-infected (n = 24) patients. Co-infected patients had decreased intrahepatic mRNA levels of IFN-gamma (P = 0.09), IL-4 (P = 0.05) and IL-12p35 (P = 0.04) compared with mono-infected patients, while IL-10 was increased (P = 0.07). In co-infected patients, IFN-gamma mRNA levels increased linearly with increasing peripheral CD4+ cell counts by 1.23 times relative to the calibrator for every 100 CD4+ cells/mm(3) increase (P = 0.02). No other cytokines were significantly associated with CD4+ cell counts. In conclusion, HIV-induced lymphopenia may result in hepatic inflammator...Continue Reading

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Citations

Apr 11, 2009·Current HIV/AIDS Reports·Kenneth A Lichtenstein
Oct 22, 2008·Expert Reviews in Molecular Medicine·Barbara Roe, William W Hall
Nov 14, 2008·AIDS·Andrew N PhillipsJens D Lundgren
Jul 11, 2009·The Journal of International Medical Research·L L TangK Z Liu
Oct 18, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Aimee C HodowanecGregory D Huhn

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