Hepatic injuries of hexachloroethane smoke inhalation: the first analytical epidemiological study

Toxicology
Ching-Hui LohYeong-Hwang Chen

Abstract

There has been no human epidemiological data regarding the hepatic injuries of hexachloroethane-zinc oxide (HC/ZnO) inhalation. This is the first epidemiological study to investigate whether HC/ZnO inhalation exposure can induce hepatic dysfunction in exposed soldiers. Twenty soldiers, exposed to high concentration of HC/ZnO smoke for 3-10 min in a narrow tunnel (0.6 m in width) during military training, were recruited as exposed group and they were divided into high-exposed group (n=10) and low-exposed group (n=10) by the distance from the explosion locale as a surrogate of exposure condition. Another 64 soldiers, not visiting the explosion areas, were recruited as referents. Venous blood was collected for liver function analyses. After log transformation of alanine aminotransferase (ALT) and adjustment for potential confounders, serum ALT in high-exposed soldiers was statistically significantly higher than those of referents for the 3 weeks following exposure. The serum ALT in low exposed soldiers was statistically significantly higher than those of referents at the 3rd week following exposure. The mean ALT levels also showed decreasing gradients by the distance from exposure locale. In addition, the proportions of abnormalit...Continue Reading

References

Jan 1, 1988·Archives of Toxicology·T C MarrsN L Cross
Jan 1, 1988·Intensive Care Medicine·E HjortsøW M Zapol
Jan 1, 1985·International Archives of Occupational and Environmental Health·M Døssing, P Skinhøj
Nov 5, 1997·American Journal of Industrial Medicine·M T WuD C Christiani
Nov 24, 1999·The American Journal of Gastroenterology·T NankiN Miyasaka
Feb 1, 2000·Respiratory Medicine·B ZerahnI L Kanstrup
Apr 28, 2000·Intensive Care Medicine·V PettiläP Tukiainen
Jun 21, 2002·The American Journal of the Medical Sciences·Ronald A GreenfieldMichael S Bronze
Feb 17, 2006·The New England Journal of Medicine·Victor J Navarro, John R Senior
May 6, 2006·Environmental Health Perspectives·Ching-Hui LohHong-I Chen
Aug 24, 2006·The Annals of Pharmacotherapy·Firdevs TopalEmin Altiparmak

❮ Previous
Next ❯

Citations

Sep 4, 2012·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Cheng-Hsiu ChouChing-Hui Loh
Jan 12, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Ayman El IdrissiMarcel A G van der Heyden
Apr 14, 2010·Inhalation Toxicology·Cheng-Hsiu ChouChing-Hui Loh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.