Hepatic injury correlates with neuropsychologic impairment

The International Journal of Neuroscience
R E TarterD H Van Thiel

Abstract

Five liver injury measures (albumin, prothrombin time, gamma globulin, indocyanine green clearance and serum ammonia) were correlated with neuropsychologic test performance in a group of 79 nonalcoholic cirrhotic patients. Employing linear regression analysis techniques revealed that these five measures, particularly albumin and prothrombin time, could explain a significant amount of the variance on neuropsychological tests. The results indicate that functional liver status, even where there is no overt evidence of hepatic encephalopathy, is related to cognitive capacity.

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Citations

May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AmodioA Gatta
Sep 1, 1992·Neuropsychology Review·D A Solomon, P F Malloy
Jun 14, 2000·Journal of Hepatology·M GroenewegS W Schalm
Jan 15, 2013·Gastroenterology Research and Practice·Irena Ciećko-MichalskaTomasz Mach
May 25, 2005·Journal of Nutrition for the Elderly·Monica S LewisSally P Stabler
May 29, 2010·Digestive Diseases and Sciences·Radha K DhimanYogesh Chawla
Dec 1, 1995·Baillière's Clinical Gastroenterology·G Masterton, R E O'Carroll
Aug 19, 2000·The American Journal of Gastroenterology·I J HartmannS W Schalm
Jul 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·I Collis, G Lloyd
Sep 19, 1998·The American Journal of Drug and Alcohol Abuse·G PanzakD H Van Thiel
Sep 17, 2005·Metabolic Brain Disease·Charmaine A Stewart, Jane Cerhan

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