Hepatic ischemic preconditioning provides protection against distant renal ischemia and reperfusion injury in mice.

Journal of Korean Medical Science
Jung Ah LeeJin Deok Joo

Abstract

We previously demonstrated that there are acute and delayed phases of renal protection against renal ischemia and reperfusion (IR) injury with renal ischemic preconditioning (IPC). This study assessed whether hepatic IPC could also reduce distant renal IR injury through the blood stream-mediated supply of reactive oxygen species (ROS). Male C57BL/6 mice were randomly divided into four groups: group I, sham operated including right nephrectomy; group II (IR), left renal ischemia for 30 min and reperfusion injury; group III (IPC-IR), hepatic ischemia for 10 min followed by 10 min of reperfusion before left renal IR injury; group IV (MPG - IPC + IR), pretreated with 100 mg/kg N-(2-mercaptopropionyl)-glycine (MPG) 15 min before hepatic IPC and left renal IR injury. Renal function, histopathologic findings, proinflammatory cytokines, and cytoprotective proteins were evaluated 15 min or 24 hr after reperfusion. Hepatic IPC attenuated the expression of proinflammatory cytokines, tumor necrosis factor α, intercellular adhesion molecule 1, and induced inducible nitric-oxide synthase, and the phosphorylation of Akt in the murine kidney. Renal function was better preserved in mice with hepatic IPC (group III) than groups II or IV. Hepatic...Continue Reading

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Citations

Apr 8, 2014·World Journal of Gastroenterology : WJG·Carlos Rodrigo Camara-Lemarroy
May 7, 2014·Oxidative Medicine and Cellular Longevity·Constantinos NastosNikolaos Arkadopoulos
Apr 10, 2013·Journal of Hepatology·Catherine BrennerGuido Kroemer
Jun 16, 2015·World Journal of Gastroenterology : WJG·Bin ShiHong-Yi Zhang
Jul 10, 2013·Experimental and Therapeutic Medicine·Cimen Gülben OlgunerSerap Cilaker Micili
May 13, 2018·International Journal of Molecular Sciences·Jinyang WangWenhua Huang

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Methods Mentioned

BETA
dissection
electrophoresis
PCR

Software Mentioned

SPSS

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