DOI: 10.1101/499566Dec 19, 2018Paper

Hepatic JARID1a ablation disrupts the transcription adaptation to feeding and alters systemic metabolism

BioRxiv : the Preprint Server for Biology
Kacee A DiTacchioLuciano DiTacchio

Abstract

The liver is a key regulator of systemic energy homeostasis whose proper function is dependent on the circadian clock. Here, we show that livers deficient in the oscillator component JARID1a exhibit a dysregulation of genes involved in energy metabolism. Importantly, we find that mice that lack hepatic JARID1a have decreased lean body mass, decreased respiratory exchange ratios, faster production of ketones and increased glucose production in response to fasting. Finally, we find that JARID1a loss compromises the response of the hepatic transcriptome to nutrient availability. In all, ablation of hepatic JARID1a disrupts the coordination of hepatic metabolic programs with whole-body consequences.

Related Concepts

Energy Metabolism
Genes
Ketones
Liver
Laboratory mice
Physiological Aspects
KDM5A protein, human
Adaptation
Ablation
Respiratory Gaseous Exchange in Organisms

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