PMID: 16613099Apr 15, 2006Paper

Hepatic lesion in patients with hepatocerebral dystrophy

Terapevticheskiĭ arkhiv
G V SukharevaL B Lazebnik

Abstract

To study hepatic affection in hepatocerebral dystrophy (HCD) regarding clinical course and duration of the disease. The records on 63 HCD patients were studied retrospectively as to early clinical symptoms, onset dynamics, biochemical tests for hepatic function, morphological changes of the liver, immune and cytokine status, markers of hepatotropic viruses. Six variants of HCD course were identified: hepatic (24 patients), endocrine (17 patients), neurological (12 patients), psychoemotional (5 patients), hemolytic (3 patients), renal (1 patient). Early hepatitis and hepatic cirrhosis progress were characteristic for the hepatic variant. The other variants were characterized by hepatic fibrosis, lipofuscinosis, fat dystrophy of the liver. Markers of viral hepatitides B, C, G, TT were detected primarily in patients with a hepatic variant of HCD. A moderate rise of aminotransferases, immunoglobulins, cytokines level indicate weak inflammation in hepatic tissue. Disorders in proteins synthesis, hepatic detoxication function reflect changes in the microsomal system and endoplasmic network. Hepatic lesions in HCD are different. Clinical, biochemical, morphological activity and immune status affections were most severe in patients wit...Continue Reading

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