Hepatic lipase activity is decreased in Japanese patients with type III hyperlipoproteinemia

Clinica Chimica Acta; International Journal of Clinical Chemistry
Toshio MuraseMinoru Okubo

Abstract

Type III hyperlipoproteinemia (HLP), a disorder associated with a high incidence of premature cardiovascular diseases, is characterized by the accumulation of remnant lipoproteins in the plasma. The primary genetic defect in patients with type III HLP is the presence of apolipoprotein E2 (apoE2), an isoform of apoE, and accumulation of remnant lipoproteins in the plasma has been thought to be attributable to the presence of apoE2, which bind poorly to low density lipoprotein receptors, resulting in defective remnant lipoprotein clearance. On the other hand, the activity of hepatic lipase (HL), the enzyme that plays a pivotal role in the removal of remnant lipoproteins, in type III HLP has not been investigated. We examined post-heparin plasma lipoprotein lipase (LPL) and HL activities in 7 patients with type III HLP. The activities of HL and LPL in post-heparin plasma were measured separately by an immunochemical method using antiserum specifically directed against HL. The post-heparin plasma HL activity was significantly reduced, while the LPL activity was normal. Reduced HL activity may account, at least in part, for the accumulation of remnant lipoproteins in the plasma, a characteristic feature of type III HLP.

References

Feb 1, 1983·Metabolism: Clinical and Experimental·T MuraseH Uchimura
Jul 1, 1980·Metabolism: Clinical and Experimental·T MuraseS Yoshida
Aug 1, 1980·Metabolism: Clinical and Experimental·T Murase, H Uchimura
Jan 1, 1994·Journal of Atherosclerosis and Thrombosis·K NakajimaT Murase
Jun 30, 1998·Current Opinion in Lipidology·S Santamarina-FojoM Amar
Mar 18, 2003·Journal of Lipid Research·Samir S DeebJohn D Brunzell
Nov 27, 2008·European Journal of Human Genetics : EJHG·Peter HennemanAugustinus H M Smelt

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Citations

Aug 1, 2014·Current Atherosclerosis Reports·Paul N HopkinsM Nazeem Nanjee
Jul 21, 2015·Biochimica Et Biophysica Acta·Peng Yang, Papasani V Subbaiah
Jan 11, 2014·Critical Reviews in Clinical Laboratory Sciences·A D MaraisD J Blom

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