PMID: 11906928Mar 22, 2002Paper

Hepatic lipase deficiency attenuates mouse ovarian progesterone production leading to decreased ovulation and reduced litter size

Biology of Reproduction
Randy L WadeCheryl A Dyer

Abstract

The lipolytic enzyme hepatic lipase (HL) may facilitate mobilization of cholesterol substrate for ovarian steroidogenesis. We investigated whether HL was necessary for optimum reproduction in the female mouse by analyzing breeding performance and ovarian responses to gonadotropins in HL-/- mice. HL-/- female mice bred with HL-/- males had the same pregnancy success rate and pup survival rate as did wild-type (WT) mice but had significantly smaller litters, producing 1.7 fewer pups per litter. Mice were primed with eCG/hCG, and at 6 h post-hCG the HL-/- mice had smaller ovaries than did the WT mice. HL deficiency specifically affected ovarian weight; adrenal gland weights did not differ between WT and HL-/- mice. HL-/- mice weighed more than age-matched WT mice. Between the two mouse genotypes, uterine weights were the same, indicating that estrogen production was equivalent. However, the HL-/- ovaries produced significantly less progesterone than did the WT ovaries within 6 h of hCG stimulation. HL-/- ovaries had the same number of large antral follicles as did the WT ovaries but had fewer hemorrhagic sites, which represent ovulations, fewer corpora lutea, and more oocytes trapped in corpora lutea. We suggest that reduced proge...Continue Reading

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Citations

Apr 25, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Kylie R DunningRebecca L Robker
Nov 4, 2009·Molecular and Cellular Endocrinology·D BussoR D Moreno
Mar 19, 2005·The Journal of Clinical Investigation·Ying YuColin D Funk
Jun 15, 2007·Biochimica Et Biophysica Acta·Christopher GunterSuzanne Jackowski
Nov 2, 2006·Endocrine Reviews·Carlos StoccoGeula Gibori

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