Hepatic lipid profiling in chronic hepatitis C: an in vitro and in vivo proton magnetic resonance spectroscopy study.

Journal of Hepatology
Jeremy F L CobboldSimon D Taylor-Robinson

Abstract

Hepatic steatosis is an important factor in pathogenesis, progression and response to treatment in hepatitis C. We aimed to investigate differences in hepatic lipid composition in liver biopsies from patients with chronic hepatitis C using proton magnetic resonance spectroscopy ((1)H MRS) and to translate these findings to the in vivo clinical setting. Two cohorts of patients with histologically defined chronic hepatitis C were studied. High-resolution MR spectra were obtained from 47 liver biopsy samples. These data were used to derive biologically relevant prior knowledge for the assignment and interpretation of lower-resolution in vivo hepatic MRS data acquired at 1.5T from a second cohort of 59 patients. MRS data were obtained both in vitro and in vivo from a subset of 11 patients. Multivariate factor analysis demonstrated characteristic MR spectral differences by fibrosis stage and genotype. Total lipid increased with fibrosis stage (r=0.43, p=0.003) and was higher in genotype 3 compared to genotype 1 (p=0.03), while lipid polyunsaturation decreased with increasing fibrosis stage (r=-0.55, p<0.0005) and, independently, with increasing steatosis. Non-invasive assessment using in vivo hepatic (1)H MRS corroborated in vitro f...Continue Reading

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Citations

Jun 24, 2010·The Proceedings of the Nutrition Society·Jeremy F L CobboldSimon D Taylor-Robinson
Mar 22, 2012·Journal of Gastroenterology and Hepatology·Jeremy F L CobboldSimon D Taylor-Robinson
Mar 30, 2013·World Journal of Gastroenterology : WJG·Li XuJin-Zhi Zheng
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Jan 13, 2016·World Journal of Gastroenterology : WJG·Roland AmathieuLaurence Le Moyec
Nov 9, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pierre NahonLaurence Le Moyec
Jul 15, 2020·Journal of Proteome Research·Anjana PathaniaRajat Sandhir

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