Hepatic malignancies: improved treatment with intraarterial Y-90

Radiology
Milton J HerbaP M Bret

Abstract

An improved treatment method for hepatic malignancies with yttrium-90 incorporated into the matrix of glass microspheres was evaluated prospectively. Fifteen patients with 12 metastatic colorectal cancers, one carcinoid, one islet cell tumor, and one hepatoma were treated with three dose levels: 5,000 cGy (5,000 rad), ten patients; 7,500 cGy (7,500 rad), three patients; and 10,000 cGy (10,000 rad), two patients. Mean follow-up was 7 months (range, 2-12 months). Stable disease in the liver was seen in ten patients, four of whom had concurrent progression of extrahepatic disease, which resulted in two deaths. Two additional deaths were not directly related to the malignant process. Progression of liver disease was found in five patients, with three deaths occurring at 7-8 months. No procedural, hematologic, or pulmonary complications occurred. Late gastroduodenal ulceration occurred at 6-8 weeks in three patients who had histories of chronic alcohol abuse. This method of therapy seems to be feasible and efficient. Caution is necessary with high doses or with patients with a history of or predisposition to gastroduodenal ulcers.

Citations

Nov 11, 2010·Cardiovascular and Interventional Radiology·Justin P McWilliamsDavid M Liu
Jan 22, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Sanjeeva P KalvaStephan Wicky
Oct 18, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ravi MurthyMarshall E Hicks
Mar 20, 2004·Radiology·Johannes F W NijsenAlfred D van het Schip
Apr 16, 2002·Seminars in Oncology·Milton J Herba, Michael P Thirlwell
May 1, 1991·Seminars in Surgical Oncology·S Nag
Mar 5, 1998·International Journal of Radiation Oncology, Biology, Physics·W Y LauA K Li
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·N ArakiT Kokubo
Jan 1, 1991·European Journal of Nuclear Medicine·C A Hoefnagel
Apr 21, 2010·Annals of Surgical Oncology·Eleni Liapi, Jean-Francois H Geschwind
Mar 22, 2001·Nuclear Medicine Communications·S D ChenS J Wang
Apr 21, 2010·The Cancer Journal·Andrew S Kennedy, Riad Salem
Sep 27, 2006·Cancer Biotherapy & Radiopharmaceuticals·Ching-Yee Oliver WongRiad Salem
May 30, 2008·Cardiovascular and Interventional Radiology·Saad M IbrahimRiad Salem
Feb 17, 2005·Journal of Vascular and Interventional Radiology : JVIR·James E GoinKenneth G Thurston
Aug 23, 2006·Journal of Vascular and Interventional Radiology : JVIR·David C MadoffJames C Yao
Jul 1, 1991·International Journal of Radiation Oncology, Biology, Physics·R A FoxB N Gray
Jul 21, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Shuyi LiWilliam S Dynan
Aug 30, 2008·Surgical Oncology Clinics of North America·Gregory J Dubel, Gregory M Soares
May 25, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Misara HamoudehHatem Fessi
Oct 2, 2002·Journal of Vascular and Interventional Radiology : JVIR·Riad SalemJean-Francois H Geschwind
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Brian I Carr
Nov 4, 2009·IEEE Transactions on Medical Imaging·Alexander S Pasciak, William D Erwin
Jul 1, 1989·Current Problems in Cancer·N Kemeny, A Schneider
Jan 1, 1991·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·P A SchubigerW Schilt
May 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Andrew S KennedyScott Sailer
Mar 11, 2006·Surgical Oncology·Sean Garrean, N Joseph Espat
Oct 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J H AndersonC S McArdle
Apr 30, 2014·Diagnostic and Interventional Imaging·G VesselleJ-P Tasu
Jan 1, 1997·Journal of Biomedical Materials Research·M KawashitaK Kajiyama
Nov 1, 1994·The British Journal of Surgery·S BhattacharyaK E Hobbs
Jul 1, 1992·The British Journal of Surgery·W Y Lau, A K Li
Aug 1, 1991·The British Journal of Surgery·J R NovellK E Hobbs
Oct 1, 1993·Journal of Biomedical Materials Research·E M Erbe, D E Day
May 27, 2004·World Journal of Gastroenterology : WJG·Dong-Sheng ZhangQun-Hui Li
Oct 15, 2008·The American Journal of Surgical Pathology·Clinton D CrowderKenneth P Batts
Jan 10, 2019·Journal of Clinical Medicine·Aman SainiRahmi Oklu
Mar 8, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Juan C SpinaRicardo Garcia Monaco
May 29, 2019·Nuclear Medicine Communications·Trifon SpyridonidisKonstantinos Katsanos
Nov 1, 1996·Physics in Medicine and Biology·S F Zavgorodni
Dec 24, 2019·Nuclear Medicine and Molecular Imaging·Eun Jeong LeeYoung So
Jun 20, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Vanessa L GatesRiad Salem

Related Concepts

Related Feeds

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.

Carcinoma, Islet Cell

Islet Cell Carcinoma or Pancreatic Neuroendocrine Tumours arises in the hormone producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Carcinoma here.

Carcinoma, Islet Cell (Keystone)

Islet Cell Carcinoma or Pancreatic Neuroendocrine Tumours arise in the hormone producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on islet cell carcinoma in this feed.