Hepatic micrometastases are associated with poor prognosis in patients with liver metastases from neuroendocrine tumors of the digestive tract

Human Pathology
William E GibsonChanjuan Shi

Abstract

Pathologic examination of hepatic metastasectomies from patients with metastatic small intestinal or pancreatic neuroendocrine tumor frequently reveals micrometastases undetectable by radiologic or macroscopic gross examination. This finding raises the possibility that undetectable micrometastases remain in these patients after metastasectomy. Here we examined liver resections for micrometastases and assessed their impact on prognosis. Hepatic metastasectomies from 65 patients with neuroendocrine tumor of the small intestine (N = 43) or pancreas (N = 22) were reviewed for the presence of micrometastases, which were defined as microscopic tumor foci ≤1 mm in greatest dimension. Medical records were also reviewed for patient demographics, clinical history, and follow-up data. Micrometastasis was identified in 36 (55%) of 65 hepatic resection specimens. More hepatic micrometastases were seen in small intestinal cases than in pancreatic cases (29/43, 67%, versus 7/22, 32%; P < .01). They were typically present within portal tracts, sometimes with extension into the periportal region or sinusoidal spaces away from the portal tracts. Patients without hepatic micrometastases had fewer macrometastases or more R0 hepatic resections than...Continue Reading

Citations

Oct 26, 2018·The Journal of Clinical Endocrinology and Metabolism·Anna MalczewskaIrvin M Modlin
Sep 27, 2019·Endocrine Reviews·Johannes HoflandWouter W de Herder
Jul 1, 2020·Zentralblatt für Chirurgie·Florian BöschJens Werner
Jul 28, 2020·Journal of Clinical Medicine·Sophie DeguelteReza Kianmanesh
Dec 17, 2019·Advances in Medical Sciences·Anna MalczewskaIrvin M Modlin
Sep 22, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Michael LineckerAndrea Frilling
Nov 5, 2021·Acta Veterinaria Scandinavica·Mikael KerboeufLars Moe

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