Hepatic microRNA profiles offer predictive and mechanistic insights after exposure to genotoxic and epigenetic hepatocarcinogens

Toxicological Sciences : an Official Journal of the Society of Toxicology
Costas KoufarisNigel J Gooderham

Abstract

In recent years, accumulating evidence supports the importance of microRNAs in liver physiology and disease; however, few studies have examined the involvement of these noncoding genes in chemical hepatocarcinogenesis. Here, we examined the liver microRNA profile of male Fischer rats exposed through their diet to genotoxic (2-acetylaminofluorene) and epigenetic (phenobarbital, diethylhexylphthalate, methapyrilene HCL, monuron, and chlorendic acid) chemical hepatocarcinogens, as well as to non-hepatocarcinogenic treatments (benzophenone, and diethylthiourea) for 3 months. The effects of these treatments on liver pathology, plasma clinical parameters, and liver mRNAs were also determined. All hepatocarcinogens affected the expression of liver mRNAs, while the hepatic microRNA profiles were associated with the mode of action of the chemical treatments and corresponded to chemical carcinogenicity. The three nuclear receptor-activating chemicals (phenobarbital, benzophenone, and diethylhexylphthalate) were characterized by the highly correlated induction of the miR-200a/200b/429, which is involved in protecting the epithelial status of cells and of the miR-96/182 clusters. The four non-nuclear receptor-activating hepatocarcinogens w...Continue Reading

References

Mar 1, 1978·British Journal of Cancer·W H Butler
Jan 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·W Lijinsky
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert TibshiraniGilbert Chu
Dec 14, 2004·Toxicology·Paula J LapinskasJ Christopher Corton
Apr 5, 2005·Toxicologic Pathology·Jerry F Hardisty, Amy E Brix
Sep 13, 2005·Toxicology and Applied Pharmacology·Rob C Aalberse
May 11, 2006·Drug Metabolism Reviews·Susumu Kodama, Masahiko Negishi
Aug 19, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ivy D MoffatAllan B Okey
May 23, 2009·Cell Death and Differentiation·H Hermeking
Jul 28, 2009·Mutation Research·Lya G HernándezJan van Benthem
Sep 12, 2009·Clinical Chemistry·Omar F LaterzaWarren E Glaab
Oct 28, 2009·Carcinogenesis·Philippe Irigaray, Dominique Belpomme
Dec 5, 2009·World Journal of Gastroenterology : WJG·Shashi BalaGyongyi Szabo
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Pascal PineauAnne Dejean
Jan 8, 2010·BMC Genomics·Claire L WatermanJulian L Griffin
Jun 22, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wei DingC Bart Rountree
Jul 14, 2010·Toxicology and Applied Pharmacology·Weihua GaoTetsuro Urushidani
Jul 29, 2010·Cancer Research·Derek M Dykxhoorn
Mar 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Amar Deep SharmaTobias Cantz
Apr 27, 2011·The Journal of Experimental Medicine·Taewan KimCarlo M Croce
Oct 20, 2011·Cancer Research·Jong-Kook ParkThomas D Schmittgen

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Citations

Oct 26, 2013·Toxicology·Costas KoufarisNigel J Gooderham
Oct 24, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Costas Koufaris, Nigel J Gooderham
Feb 25, 2014·International Journal of Hygiene and Environmental Health·A Izzotti, A Pulliero
Aug 8, 2014·Experimental and Molecular Pathology·Hamidreza MaroofAlfred King-Yin Lam
Mar 6, 2015·Expert Opinion on Drug Metabolism & Toxicology·April K MarroneIgor P Pogribny
Aug 30, 2014·Expert Opinion on Drug Metabolism & Toxicology·April K MarroneIgor P Pogribny
Nov 27, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·April K MarroneIgor P Pogribny
Jan 3, 2016·Environmental Toxicology and Pharmacology·Hongyan DongMichael G Wade
Mar 17, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Vicky Nicolaidou, Costas Koufaris
Aug 16, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Evrim AnadolJonel Trebicka
Sep 20, 2015·Toxicon : Official Journal of the International Society on Toxinology·Caixia LiuQing Wang
Nov 25, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Alessandro SinigagliaLuisa Barzon
Dec 3, 2014·Developmental and Comparative Immunology·Nathan J DennisonGeorge Dimopoulos
Mar 9, 2013·International Journal of Biological Macromolecules·A MoorthiN Selvamurugan
May 6, 2014·Toxicology Letters·N J Gooderham, C Koufaris
Feb 4, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Bénazir SiddeekMohamed Benahmed
Nov 21, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nadine KosslerArno Kalkuhl
Jun 9, 2016·Environmental Toxicology and Pharmacology·Yongyong ZhouJiangfeng Guo
Oct 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Aline de ContiIgor P Pogribny
Oct 29, 2013·Journal of Proteome Research·Zsuzsanna AmentJulian L Griffin
Sep 25, 2016·Regulatory Toxicology and Pharmacology : RTP·Achim AignerAlan Poole
Nov 23, 2017·Drug and Chemical Toxicology·Simon LoiodiceFranck Atienzar
May 19, 2020·Toxicology and Industrial Health·Vicky Nicolaidou, Costas Koufaris
Feb 3, 2018·World Journal of Gastroenterology : WJG·Xing-Ya GuoJian-Gao Fan

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