PMID: 1195021Dec 1, 1975Paper

Hepatic microsomal enzyme induction in rats fed varietal cauliflower leaves

The Journal of Nutrition
J G Babish, G S Stoewsand

Abstract

Leaves from a standard, insect-susceptible cauliflower variety and an insect-resistant strain were formulated at either 10 or 25% into semipurified diets for male and female weanling rats. After 3 weeks, relative liver weights, microsomal protein, cytochrome P-450, and activities of hepatic microsomal aminopyrine N-demethylase, aniline hydroxylase, p-nitroanisole O-demethylase, and N-methylaniline N-demethylase were determined. Growth, feed intake, and feed efficiency of male rats were not affected by the inclusion of the dried cauliflower leaf in the diet. However, female rats exhibited a depressed feed intake and increased feed efficiency with cauliflower leaf supplemental diets. Relative liver weights increased with increasing percentage of cauliflower leaves in the diet. Hepatic microsomal enzyme response to cauliflower leaf supplementation of the diet was greater in males than in females. Only aniline hydroxylase activity remained unchanged by the test diets. Male rats showed significant increases in N- and O-demethylation with both the 10 and 25% cauliflower diets, and increased values for microsomal protein and cytochrome P-450 at the 25% supplemental level. Female rats did not show significant hepatic microsomal inducti...Continue Reading

Citations

Jan 1, 1979·Drug Metabolism Reviews·L B Brattsten
Jan 1, 1983·Critical Reviews in Food Science and Nutrition·G R FenwickW J Mullin
May 1, 1984·Archives of Environmental Contamination and Toxicology·G S StoewsandD J Lisk
Jan 1, 1982·Archives of Environmental Contamination and Toxicology·J N BoydD J Lisk
Nov 1, 1977·Journal of Toxicology and Environmental Health·J G Babish, G S Stoewsand
Apr 1, 1978·Environmental Health Perspectives·J G BabishD J Lisk
Apr 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K E Aspry, L F Bjeldanes
Aug 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Hendrich, L F Bjeldanes
Dec 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C A Bradfield, L F Bjeldanes
Aug 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J P Whitty, L F Bjeldanes
Oct 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C A BradfieldL F Bjeldanes
Oct 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M KoreM A Wallig
Apr 1, 1978·Food and Cosmetics Toxicology·J G Babish, G S Stoewsand
Jun 1, 1982·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K Nishie, E Daxenbichler

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