Hepatic microsomal ethanol-oxidizing system (MEOS): increased activity following propylthiouracil administration

Alcoholism, Clinical and Experimental Research
F MorenoR Teschke

Abstract

Treatment for 7 days with the thyreostatic drug propylthiouracil (5 mg/100 g of body weight) resulted in a hypothyroid hepatic state as shown by the marked decreased hepatic content of thyroxine and triiodothyronine. This regimen led to an enchanced activity of the microsomal ethanol-oxidizing system, whereas the activities of alcohol dehydrogenase and catalase remained unchanged. Moreover, a hyperthyroid hepatic state achieved following the daily administration of L-thyroxine (150 micrograms/100 g of body weight) or L-3,3', 5-triiodothyronine (10 micrograms/100 g body weight) for 7 days resulted in a similar increased activity of the microsomal ethanol-oxidizing system. Under these conditions, a decrease of alcohol dehydrogenase activity and an unaffected catalase activity was observed. These findings, therefore, show that the administration of either propylthiouracil or thyroid hormones results in an increased activity of the microsomal ethanol-oxidizing system, suggesting that the underlying mechanism for the induction of the microsomal ethanol-oxidizing system by propylthiouracil is independent of the action of thyroid hormones.

References

Jan 1, 1977·Alcoholism, Clinical and Experimental Research·E R Gordon
Jan 1, 1977·Alcoholism, Clinical and Experimental Research·A I CederbaumE Rubin
Aug 13, 1979·Biochemical and Biophysical Research Communications·F MorenoG Strohmeyer
Oct 1, 1978·The American Journal of Digestive Diseases·R R CaponeJ A Balint
Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C S LieberE Rubin
Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·Y IsraelJ M Phillips
Mar 10, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·R D HeschH D Söling
Dec 1, 1974·Archives of Biochemistry and Biophysics·A I CederbaumE Rubin
Mar 1, 1971·Annals of Internal Medicine·R A HelmanH J Fallon
Jun 1, 1971·The American Journal of Digestive Diseases·M W LischnerJ T Galambos
Apr 18, 1968·The New England Journal of Medicine·E Rubin, C S Lieber
Jan 1, 1980·Alcoholism, Clinical and Experimental Research·P H Pikkarainen, C S Lieber
Dec 29, 1960·The New England Journal of Medicine·M GOLDBERGM HUROWITZ
Jul 5, 1962·The New England Journal of Medicine·H KALANTR CHARLEBOIS

❮ Previous
Next ❯

Citations

Jan 1, 1986·Alcoholism, Clinical and Experimental Research·R Teschke, J Gellert
Jan 1, 1984·Journal of Neural Transmission·D J HealC K Atterwill
Jul 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A SzilagyiR H Resnick
Jul 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R TeschkeG Strohmeyer
Jul 1, 1982·Journal of Endocrinological Investigation·R Teschke, B Wiese

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.