Hepatic mitochondrial function in Hereford steers with divergent residual feed intake phenotypes

Journal of Animal Science
Alberto CasalMariana Carriquiry

Abstract

Variations in phenotypic expression of feed efficiency could be associated with differences or inefficiencies in mitochondria function due to its impact on energy expenditure. The aim of this study was to determine hepatic mitochondrial density and function in terms of respiration, gene and protein expression, and enzyme activity of mitochondrial respiratory complex proteins, in steers of divergent residual feed intake (RFI) phenotypes. Hereford steers (n = 111 and n = 122 for year 1 and 2, respectively) were evaluated in postweaning 70 d standard test for RFI. Forty-six steers exhibiting the greatest (n = 9 and 16 for year 1 and 2; high-RFI) and the lowest (n = 9 and 12 for year 1 and 2; low-RFI) RFI values were selected for this study. After the test, steers were managed together until slaughter under grazing conditions until they reached the slaughter body weight. At slaughter, hepatic samples (biopsies) were obtained. Tissue respiration was evaluated using high-resolution respirometry methods. Data were analyzed using a mixed model that included RFI group as fixed effect and slaughter date and year as a random effect using PROC MIXED of SAS. RFI and dry matter intake were different (P < 0.001) between low and high-RFI group...Continue Reading

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Citations

Jun 21, 2019·Animal : an International Journal of Animal Bioscience·A CasalM Carriquiry
Oct 12, 2019·Animal : an International Journal of Animal Bioscience·E E FernandezR D Sainz
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Mariana Mescouto LopesMarcio de Souza Duarte

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