Hepatic nervous system development

The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology
Jean-Marie DelalandeAlan J Burns

Abstract

During embryonic development, the liver emerges from the foregut as a thickening of the ventral endodermal epithelium. The embryonic liver then develops into a bud of cells that proliferates and differentiates to eventually form the largest gland of the body. Prior to birth, the primary function of the liver is hematopoietic, and the organ receives little innervation during early development. Postnatally, the role of the liver changes and many different nerve types modulate its function. Although the liver shares a common embryonic origin with other foregut derivatives, such as the gallbladder and the pancreas, the development of its innervation exhibits distinct characteristics. In this review, we summarize what is known about the development of the hepatic innervation, draw comparisons with the intrinsic innervation of the gastrointestinal tract and associated organs, and discuss the potential role of molecular signals in guiding the nerves that innervate the liver.

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Citations

Feb 7, 2006·Journal of Hepatology·David CassimanVassilis Pachnis
Jan 4, 2015·The Journal of Surgical Research·Apostolos N KandilisDina G Tiniakos
Jan 16, 2008·Virchows Archiv : an International Journal of Pathology·Dina G TiniakosAlastair D Burt
Aug 18, 2005·American Journal of Physiology. Endocrinology and Metabolism·Catherine A DicostanzoAlan D Cherrington
Nov 25, 2020·Trends in Neurosciences·Eugene E LinRejji Kuruvilla
Jul 8, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hayden TorresAndrea Zsombok

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