Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Bryon E PetersenG K Michalopoulos

Abstract

Administration of 2-acetylaminofluorene (2-AAF) given before partial hepatectomy (PHx) results in suppression of hepatocyte proliferation and stimulation of oval cell proliferation. Our objective in this study was to examine the oval cell response and associated alpha-fetoprotein (AFP) gene expression by combining 2-AAF with selective damage of centrilobular regions (carbon tetrachloride [CCl4]) or periportal regions (allyl alcohol [AA]). Centrilobular damage results in a more enhanced oval cell response and AFP gene expression than periportal damage. Conversely, more intense proliferation of intraportal bile duct epithelia was seen with 2-AAF/AA than with 2-AAF/CCl4. The oval cell response and AFP gene expression was ranked as 2-AAF/ CCl4 > or = 2-AAF/PHx > 2-AAF/AA. AFP mRNA expression was also examined in an acute AA and CCl4 injury. We found very little AFP gene expression compared with the 2-AAF/hepatic injury models. To see a true oval cell response, the hepatocytes must be inhibited from proliferating. In addition, the results presented with the 2-AA/AA model suggest that the periportal matrix may be as important as the cells that populate the area.

References

Apr 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P M LindroosG K Michalopoulos
May 31, 1991·Biochemical and Biophysical Research Communications·T KinoshitaT Nakamura
May 31, 1991·Biochemical and Biophysical Research Communications·R ZarnegarG K Michalopoulos
Sep 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H K WolfG K Michalopoulos
Jan 1, 1990·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·D C HixsonN L Thompson
Nov 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S A BelinskyR G Thurman
Aug 1, 1972·The Biochemical Journal·F Serafini-Cessi
Oct 1, 1984·The Journal of Cell Biology·S J BurwenA L Jones
Sep 11, 1984·Nucleic Acids Research·L Muglia, J Locker
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R J St HilaireA L Jones
Jun 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L YavorkovskyS Sell
Dec 1, 1993·Proceedings of the Society for Experimental Biology and Medicine·M D DabevaD A Shafritz
Dec 1, 1993·Proceedings of the Society for Experimental Biology and Medicine·S S ThorgeirssonZ Hu

❮ Previous
Next ❯

Citations

Apr 14, 2005·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·S KönigH Becker
Jun 3, 2009·Pediatric Surgery International·Henning Cornelius FiegelUdo Rolle
Jul 31, 2007·Histochemistry and Cell Biology·Chien-Chang ChiuDing-Shinn Chen
Dec 7, 2006·Cell and Tissue Research·Adriana Ribeiro LeiteDaniel Giannella-Neto
Jul 5, 2005·Journal of Hepato-biliary-pancreatic Surgery·Takahisa FujikawaBryon E Petersen
Dec 27, 2005·Medical Molecular Morphology·Isao SakaidaKiwamu Okita
Jun 1, 2012·Hepatology International·Min ZhangJun Chen
Nov 1, 2003·Biochemical and Biophysical Research Communications·Yuki SatoEiji Kobayashi
Feb 10, 2000·The American Journal of Pathology·E Laconi
Jan 23, 1999·Current Opinion in Cell Biology·M Alison
Jun 19, 2002·Biochimica Et Biophysica Acta·Stanislav I SvetlovJames M Crawford
Aug 31, 2002·Journal of Gastroenterology and Hepatology·Kunio OkudaMasaru Miyazaki
Mar 19, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·D L Stocum
Mar 19, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·S Sell
Dec 3, 2002·Tissue Engineering·Jared W Allen, Sangeeta N Bhatia
Aug 31, 2002·Journal of Hematotherapy & Stem Cell Research·Yuri Y SautinStanislav I Svetlov
Nov 15, 2007·Stem Cells and Development·John D TerraceJames A Ross
Mar 3, 2011·Stem Cells and Development·Qiong QiuGretchen J Darlington
Aug 21, 2013·Stem Cells and Development·Veronika PappPéter Nagy
Oct 7, 2006·Current Opinion in Gastroenterology·S J Karpen, J M Crawford
Apr 22, 2008·Journal of Gastroenterology and Hepatology·Isao Sakaida
Apr 16, 2008·Journal of Gastroenterology and Hepatology·Yock Young Dan, George C Yeoh
Jul 10, 2008·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Stewart Sell
Aug 20, 2005·The Journal of Clinical Investigation·Aniela JakubowskiLinda C Burkly
Sep 19, 2009·Journal of the American Society of Nephrology : JASN·Juan A OliverQais Al-Awqati
Dec 24, 2013·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Li DingLing Xue
Dec 7, 2013·Stem Cells International·Eva KoellenspergerUwe Leimer
Jun 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lijun YangAmmon B Peck
Dec 7, 2002·Seminars in Cell & Developmental Biology·Seh Hoon OhBryon E Petersen
Nov 5, 2002·Methods : a Companion to Methods in Enzymology·Sergei ZolotukhinRichard O Snyder
Oct 6, 2009·Journal of Gastroenterology·Fusheng LiJingjing Lu
Jun 4, 2004·Expert Opinion on Biological Therapy·V MironovR R Markwald
Jan 19, 2012·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Shi-Zhu JinMing-Zi Han
Nov 5, 2010·Stem Cells International·Leora J Tesche, David A Gerber

❮ Previous
Next ❯

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