Hepatic oxidant/antioxidant status in cholesterol-fed rabbits: Effects of garlic extract

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Mehmet ArhanI Durak

Abstract

The investigation of oxidant/antioxidant status in hepatic tissues from cholesterol-fed rabbits and the establishment of possible protective effects of aqueous garlic extract on cholesterol-induced hepatic steatosis. Twenty-two of 31 white New Zealand rabbits were given cholesterol (0.5 g/kg/day) for 4 months. Seven of them were then killed (cholesterol group). The remaining 15 animals were divided into two groups. Seven were fed on a normal laboratory diet (normal diet group) and the others (extract group) on a normal diet plus garlic extract (1.5 ml/kg/day) for an additional 3 months. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) enzyme activities, antioxidant potential (AOP) value, malondialdehyde (MDA), cholesterol and triglyceride levels in the liver tissues and total cholesterol and triglyceride levels in serum samples were measured. An histological evaluation was also done. An impaired antioxidant system, reduced antioxidant defence potential and increased peroxidation were found in hepatic steatotic tissues from cholesterol-fed animals. Treatment with garlic extract caused a significant increase in antioxidant potential and partly eliminated peroxidation damage in the hepatic tissue. Additi...Continue Reading

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Citations

Oct 28, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Alireza JavadzadehYadollah Omidi
Mar 8, 2016·Research in Cardiovascular Medicine·Mohammad Hassan Ghosian MoghaddamMaryam Maleki
Jan 29, 2020·Journal of Animal Physiology and Animal Nutrition·Ibrahim T El-RatelHanan I El-Morsy

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