Hepatic Progenitor Cells: An Update

Gastroenterology Clinics of North America
Matthias Van Haele, Tania Roskams

Abstract

Liver regeneration is a fascinating and complex process with many medical implications. An important component of this regenerative process is the hepatic progenitor cell (HPC). These appealing cells are able to participate in the renewal of hepatocytes and cholangiocytes when the normal homeostatic regeneration is exhausted. Moreover, the HPC niche is of vital importance toward the activation, differentiation, and proliferation of the HPC. This niche provides a rich microenvironment for the regulation of the HPC, thanks to the intercellular secretion of molecules. New findings indicate that the regenerative possibilities in the liver could provide a diverse basis for therapeutic targets.

Citations

Jun 6, 2019·Nature Reviews. Gastroenterology & Hepatology·Luca FabrisMario Strazzabosco
May 15, 2019·International Journal of Molecular Sciences·Matthias Van HaeleTania Roskams
Apr 6, 2021·World Journal of Hepatology·Yana V KiselevaYuri O Zharikov
Jun 17, 2020·Mayo Clinic Proceedings. Innovations, Quality & Outcomes·Anan A Abu RmilahScott L Nyberg
Oct 9, 2020·Research in Veterinary Science·M R TavaresG H Toniollo

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