Hepatic protection by 16, 16-dimethyl prostaglandin E2 (DMPG) against acute aflatoxin B1-induced injury in the rat

Prostaglandins
B RushM Ruwart

Abstract

Studies were conducted to assess the possible protective action of 16,16-dimethyl prostaglandin E2 (DMPG) against acute aflatoxin B1 (AFB1) induced hepatic injury in the rat. Evaluation of liver damage by histopathologic techniques and clinical chemistry indicated that hepatic necrosis was ameliorated by treatment with DMPG even though binding of radiolabeled (3H)-AFB1 to hepatic DNA was unaffected by this prostaglandin. However, DMPG did not protect rats against AFB1-induced mortality. These data suggest that hepatic protection by DMPG was due to mechanisms other than an interference with the activation or hepatic binding of AFB1.

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Citations

Sep 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·K J HardyA Shulkes
May 1, 1994·Digestive Diseases and Sciences·G L MontoA K Burroughs
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Nov 22, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M M Sailaja Devi, U N Das
Jun 1, 1996·Gastroenterology Clinics of North America·M J Ruwart, K S Henley
Sep 24, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M M Sailaja Devi, Undurti Narasimha Das
Apr 30, 1999·Journal of Gastroenterology and Hepatology·J MuntanéG Miño

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