PMID: 3745882Jan 1, 1986Paper

Hepatic regenerative stimulator substance in the rabbit. Relation to liver regeneration after partial hepatectomy

Journal of Hepatology
W E FleigH Ditschuneit

Abstract

The occurrence and activity of hepatic regenerative stimulator substance was investigated in the partially hepatectomized rabbit and related to biochemical and morphological parameters of liver regeneration. Male rabbits were 60% hepatectomized by excising the Spigelian, left lateral and left central lobes of the liver leaving the gallbladder in situ. [3H]Thymidine incorporation into DNA, the fraction of labelled hepatocyte nuclei, the fraction of mitoses and thymidine kinase activity rose from basal levels at 30-40 h after hepatectomy and increased up to 12-fold at 40-60 h. After 7 days, proliferation parameters returned to near prae-hepatectomy values and 82% of the initial liver mass was restored. Hepatic regenerative stimulator substance was biologically active when prepared from rabbit livers between 18-30 h after partial hepatectomy. At 12 and 30 h after intraperitoneal injection of the extract into normal rats, hepatic DNA synthesis was stimulated up to 2-fold in a dose-dependent fashion. The biological activity was protease-sensitive and thus depended on a protein component of the extract. The data demonstrate the existence of hepatic regenerative stimulator substance in regenerating rabbit liver and suggest that it is ...Continue Reading

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Citations

Jan 1, 1992·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·J E Paulsen, K L Reichelt
Sep 6, 2003·Liver International : Official Journal of the International Association for the Study of the Liver·Alexandra P MargeliStamatios E Theocharis
Jul 11, 2012·Fibrogenesis & Tissue Repair·Chandrashekhar R Gandhi
Jan 1, 1992·Scandinavian Journal of Gastroenterology·S SkullmanJ Larsson
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·R Gebhardt
Feb 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W E Fleig, G Hoss
Apr 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M H MeiD Z Gong
Dec 29, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·LeAnne H Young, Vipul Periwal
Nov 1, 1991·Scandinavian Journal of Gastroenterology·S SkullmanJ Larsson
Jan 1, 1995·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·T L HwangM F Chen
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D R LaBrecqueJ Barton
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·W E Fleig
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Z Q YaoF Y Yang
May 1, 1991·Digestive Diseases and Sciences·D R LaBrecque
Jan 1, 1993·Journal of Surgical Oncology. Supplement·A FrancavillaT E Starzl
Dec 17, 2008·Digestive Diseases and Sciences·Georgios GribilasStamatios E Theocharis
Mar 23, 2015·Orvosi hetilap·Tibor Balogh, András Szarka

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