PMID: 3026259Jan 1, 1987

Hepatic resection for hepatocellular carcinoma. Clinical features and long-term prognosis

Annals of Surgery
T NagaoY Morioka

Abstract

Ninety-eight hepatic resections for hepatocellular carcinoma were performed on 94 patients from 1963-1985. HBs antigen was positive in 17% of patients, preoperative serum alpha-fetoprotein was more than 20 ng/mL in 70% of patients, and liver cirrhosis was present in 75% of patients. Hospital mortality rate was 19%, and the volume of operative blood loss was the most decisive factor that affected the short-term prognosis. Excluding the 19 hospital deaths, the long-term survival rates of 75 patients were 73%, 42%, and 25% for 1, 3, and 5 years, respectively. Prognostic factors that influenced the long-term prognosis were investigated by comparing the survival curves. Significant differences of survival patterns were noted when analyzed on the basis of preoperative alpha-fetoprotein level (less than or equal to 200 vs. greater than 200 ng/mL), tumor size (less than or equal to 5 vs. greater than 5 cm), and tumor capsule. The recurrence of carcinoma was the main cause of death in 56% (42 patients) who died after discharge from the hospital. The development of effective prevention and treatment against recurrent tumors is necessary to improve long-term prognosis.

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Citations

Apr 1, 1985·The British Journal of Surgery·N NagasueT Hamada
Jul 1, 1985·Annals of Surgery·T NagaoY Morioka
May 21, 1971·Prensa médica argentina·E Lopez Garcia
Oct 1, 1974·Annals of Surgery·F G MoodyJ S Aldrete
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Apr 1, 1983·Annals of Surgery·H H ThompsonW P Longmire
Mar 1, 1983·Annals of Surgery·S IwatsukiT E Starzl

Related Concepts

Neoplasm Recurrence, Local
AFP
Study, Methodological
Liver Carcinoma
Neoplasms
Postoperative Hemorrhage
Liver Cirrhosis
Hepatectomy
Carcinoma
Hemorrhage

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