Hepatic Resection for Non-functional Neuroendocrine Liver Metastasis: Does the Presence of Unresected Primary Tumor or Extrahepatic Metastatic Disease Matter?

Annals of Surgical Oncology
Jun-Xi XiangTimothy M Pawlik

Abstract

The objective of this study was to assess the impact of unresected primary tumor, as well as extrahepatic metastasis, on the long-term prognosis of patients undergoing hepatic resection for non-functional neuroendocrine liver metastasis (NF-NELM). Patients who underwent hepatic resection for NF-NELM were identified from a multi-institutional database. Data on clinical and pathological details, as well as the long-term overall survival (OS) were obtained and compared. Propensity score matching was performed to generate matched pairs of patients. Among the 332 patients with NF-NELM, 281 (84.6%) underwent primary tumor resection, while 51 (15.4%) did not. Patients who underwent primary resection were more likely to have a pancreatic primary and metachronous NELM. The long-term OS of patients who did and did not have the primary neuroendocrine tumor (NET) resected was comparable on both unmatched (10-year survival rate 66.8% vs. 54.0%, p = 0.192) and matched (10-year survival rate 75.7% vs. 60.4%, p = 0.271) analyses. In contrast, patients with NF-NELM and extrahepatic metastasis had a worse OS following resection compared with patients who had intrahepatic-only metastasis on unmatched (10-year survival rate 37.5% vs. 69.3%, p = 0....Continue Reading

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Citations

Jan 24, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Diamantis I TsilimigrasTimothy M Pawlik
May 20, 2020·World Journal of Gastrointestinal Surgery·Steven D ScovilleJordan M Cloyd
Sep 20, 2018·Annals of Surgical Oncology·Blayne A Sayed, Alice C Wei
Jun 27, 2020·The Journal of International Medical Research·Yijun XiaLong Xia
Apr 20, 2019·Journal of Surgical Oncology·Xu-Feng ZhangUNKNOWN United States Neuroendocrine Tumor Study Group

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