Hepatic resection of non-colorectal and non-neuroendocrine liver metastases - survival benefit for patients with non-gastrointestinal primary cancers - a case-controlled study

International Journal of Surgery
Jan E SlottaOtto Kollmar

Abstract

Whereas resection of colorectal liver metastases is gold standard, there is an ongoing debate on benefit of resection of non-colorectal (NCRC) and non-neuroendocrine (NNEC) liver metastases. The potential survival benefit of patients undergoing resection of NCRC or NNEC liver metastases was investigated. Data from a prospectively maintained database were reviewed over a 7-year period. Kaplan-Meier method was used for the evaluation of outcome following resection. 101 patients underwent 116 surgical procedures for synchronous and metachronous NCRC or NNEC liver metastases with a morbidity of 23% and a mortality of ∼1%. 11 patients underwent repeated liver resection procedures. Overall 5-year survival after liver resection was 30% depending on primary tumour site. Median survival was significantly increased after resection of hepatic metastases from non-gastrointestinal primaries compared to gastrointestinal primaries. Resection of hepatic metastases from non-gastrointestinal primaries resulted in significantly increased median survival compared to exploration only. Patients with hepatic metastases from gastrointestinal primaries did not benefit from hepatic surgery. Hepatic resection for liver metastases from NCRC or NNEC cancer...Continue Reading

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Citations

Aug 26, 2014·Langenbeck's Archives of Surgery·Timothy L FitzgeraldEmmanuel E Zervos
May 30, 2015·World Journal of Surgical Oncology·Fabio UggeriFabrizio Romano
Feb 28, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Tobias S SchiergensWolfgang E Thasler
Aug 5, 2016·ANZ Journal of Surgery·Nicholas A R ClarkeGuy J Maddern
Nov 1, 2016·Expert Review of Anticancer Therapy·Gonzalo Tapia RicoTimothy J Price
Apr 22, 2021·Journal of Cancer Research and Clinical Oncology·Astrid BauschkeUtz Settmacher
Dec 4, 2021·Langenbeck's Archives of Surgery·Andreas R R WeissChristina Hackl

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