Hepatic sarcoidosis in patients presenting with liver dysfunction: imaging appearance, pathological correlation and disease evolution

European Radiology
David T FetzerMitchell E Tublin

Abstract

We hypothesize that hepatic sarcoidosis is a dynamic process that can lead to cirrhosis and portal hypertension, independent of the course of thoracic disease. Therefore, we assess the imaging appearance and progression of hepatic sarcoidosis in subjects presenting with hepatic dysfunction. An IRB-approved, HIPAA-compliant, single-institution retrospective review identified 39 subjects with sarcoidosis-related liver dysfunction. Clinical information was collected. Two abdominal radiologists analyzed baseline and follow-up imaging studies, scoring features of cirrhosis. Chest CT was also analyzed. At presentation, 23 subjects (59.0 %) exhibited >3 cirrhotic features and 15 (38.5 %) >2 findings of portal hypertension. Of subjects with available follow-up, 57.9 % (19 subjects; mean interval 4.7 years) showed worsening of >3 cirrhotic features (Pearson rho = 0.58; p = 0.009). Parenchymal nodules were uncommon (25.6 %), and most regressed. Although 87.2 % of subjects were diagnosed with thoracic sarcoidosis, there was poor correlation between severity of hepatic and chest disease (Pearson rho = 0.30; p = 0.119). A mean of 7.2 years elapsed between diagnosis of pulmonary and liver involvement. Sarcoidosis may present as liver dysfunc...Continue Reading

References

Jul 25, 1977·JAMA : the Journal of the American Medical Association·E Thomas, D Micci
Sep 1, 1975·The American Journal of Medicine·C RudzkiH J Zimmerman
Jan 1, 1991·Radiology·A R BrittJ H Ellis
May 1, 1982·Gut·N M BassS Sherlock
Jul 1, 1995·Journal of Computer Assisted Tomography·S J FolzS J Swensen
Dec 1, 1993·The American Journal of Surgical Pathology·K DevaneyK G Ishak
Jan 1, 1993·Abdominal Imaging·A KesslerB B Goldberg
Sep 1, 1996·European Journal of Radiology·C HoeffelP Fornes
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Moreno-MerloD Chiasson
Nov 25, 2000·AJR. American Journal of Roentgenology·H OkazakiN Matsunaga
Sep 10, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Sergio SartoriVincenzo Abbasciano
Jun 24, 2004·Journal of Gastroenterology and Hepatology·Miry Blich, Yeouda Edoute
Jun 15, 2006·European Journal of Gastroenterology & Hepatology·Patrick T F KennedyJohn Devlin
Dec 6, 2006·European Journal of Radiology·Giuseppe BrancatelliValérie Vilgrain
Dec 27, 2006·Clinical Imaging·Spyridon P DourakisAthanasios J Archimandritis
Mar 28, 2007·Abdominal Imaging·Donald G MitchellRaphael Rubin
Oct 16, 2008·The American Journal of Gastroenterology·Ellen C EbertKlaus D Hagspiel
Mar 24, 2010·AJR. American Journal of Roentgenology·Priyanka JhaFergus V Coakley
May 20, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jason M VanattaJames D Eason
Oct 20, 2011·European Journal of Gastroenterology & Hepatology·Johanna CremersGer Koek
Nov 8, 2011·World Journal of Hepatology·Hitoshi YoshijiHiroshi Fukui
May 1, 2012·Clinics in Liver Disease·Steven L Flamm
Oct 30, 2012·Magnetic Resonance Imaging·Ana FerreiraRichard C Semelka
Jan 9, 2014·European Radiology·Paolo SpagnoloDavid M Hansell

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Citations

May 6, 2017·The Journal of Medicine and Philosophy·John Matthewson, Paul E Griffiths
Aug 11, 2020·Seminars in Respiratory and Critical Care Medicine·Geoffrey RossiMatthieu Mahévas
Aug 11, 2020·Seminars in Respiratory and Critical Care Medicine·Marloes P HuitemaMarco C Post
Apr 20, 2020·Abdominal Radiology·Hilton Leao FilhoNatally Horvat
Nov 19, 2019·Frontiers in Medicine·Mai SedkiCynthia Levy
Sep 24, 2020·Journal of Clinical Medicine·Claudio TanaMaria Adele Giamberardino
Mar 23, 2018·Abdominal Radiology·S RajeshAnkur Arora
Dec 5, 2020·The Journal of International Medical Research·Kai KangBing Chang

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