PMID: 8589351Jan 1, 1995Paper

Hepatic sinusoidal cells and sinusoidal circulation

Journal of Gastroenterology and Hepatology
K Tanikawa

Abstract

Ito cells, located in the space of Disse, extend their numerous long cytoplasmic processes to surround the sinusoidal wall. Conventional and immune electron microscopy demonstrates abundant microfilaments and a great amount of actin and myosin in these cytoplasmic processes. These morphological findings suggest the possibility of control of the sinusoidal circulation by their contraction. Two mechanisms may be involved in their contraction: namely nervous and humoral factors. Ito cells, often in close contact with the nerve endings, which contain many granules of substance P (SP), have numerous receptors for this peptide. Ito cells also have receptors for endothelin-I (ET-1), more commonly found in the periportal area of the hepatic lobule. Experimental studies using cultured Ito cells showed their contraction following treatment with ET-1 or SP. These results suggest that Ito cells play an important role in the regulation of hepatic sinusoidal circulation.

References

May 1, 1985·The Journal of Cell Biology·N C JoyceG E Palade
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M SakamotoK Tanikawa
Sep 1, 1993·Journal of Hepatology·S MøllerJ H Henriksen
Jun 6, 1931·The Journal of Physiology·U S V Euler, J H Gaddum

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Citations

Oct 26, 2000·European Journal of Pharmacology·M WanecekA Oldner
Nov 5, 1997·Journal of the American College of Surgeons·A UrakamiT E Starzl
Jan 6, 2001·Acta histochemica·I I Stoyanova, M V Gulubova
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R M ReinehrD Häussinger
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V ShahR J Groszmann
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Naoki UyamaHendrik Reynaert
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Robert S McCuskey
Apr 12, 2001·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·D UhlmannH U Spiegel
Feb 3, 2005·Gastroenterology·Richard FischerDieter Häussinger

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