Hepatic sinusoidal obstruction syndrome (SOS) reduces the effect of oxaliplatin in colorectal liver metastases

Histopathology
Celien P H VreulsAnn Driessen

Abstract

Oxaliplatin is an important chemotherapeutic agent used to reduce hepatic colorectal metastases, resulting in tumour reduction and permitting surgical resection. This treatment has significant side effects, as oxaliplatin can induce sinusoidal obstruction syndrome (SOS) in the non-tumour-bearing liver, resulting in increased morbidity. We hypothesized that SOS might impede hepatic perfusion, thereby interfering with the tumour environment and attenuate the response to the chemotherapy. From the prospective database of the Maastricht University Medical Centre we collected 50 patients with hepatic colorectal carcinoma metastases. All patients received neo-adjuvant oxaliplatin followed by partial hepatectomy. Metastases and non-tumour-bearing liver were studied histopathologically. Thirty-two of 50 (64%) patients showed SOS lesions, classified as mild (26%) and moderate-severe (38%). The response to treatment, as expressed in the tumour regression grade (TRG), was grade 1 (10%); grade 2 (14%); grade 3 (28%); grade 4 (32%) and grade 5 (16%). Statistical analysis showed that a higher grade of SOS was associated with a higher grade of TRG (P = 0.016). Developing SOS is associated with a lower tumour response to neo-adjuvant oxaliplat...Continue Reading

References

Apr 3, 2002·Seminars in Liver Disease·Laurie D DeLeveGeorge B McDonald
May 30, 2002·Annals of Surgery·Michael A ChotiJohn L Cameron
Mar 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L Rubbia-BrandtB Terris
May 20, 2004·British Journal of Cancer·J E HusbandUNKNOWN International Cancer Imaging Society
Oct 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven R AlbertsJohn H Donohue
Nov 24, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A JatoiUNKNOWN North Central Cancer Treatment Group
Jan 30, 2007·The British Journal of Surgery·R Adam
Nov 6, 2007·Seminars in Liver Disease·Laurie D DeLeve
Sep 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janice WardPhilip J Robinson
Nov 9, 2010·Clinics in Liver Disease·Laura Rubbia-Brandt
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman

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Citations

Dec 29, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G Morris-StiffK R Prasad
Jul 26, 2014·Journal of Digestive Diseases·I L Ke NalbantogluElizabeth M Brunt
Apr 4, 2016·Clinics and Research in Hepatology and Gastroenterology·Dominique-Charles Valla, Dominique Cazals-Hatem
Oct 1, 2014·The Journal of Surgical Research·Masayuki OkunoShinji Uemoto
Oct 31, 2016·Journal of Cellular Physiology·Gerald J ShamiFilip Braet
Jan 23, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Mi-Jung KimTae-You Kim
May 26, 2017·The British Journal of Surgery·J ZhaoUNKNOWN Chemotherapy-Associated Liver Injury (CALI) consortium
Sep 7, 2017·Journal of Surgical Oncology·Takuma IwaiEiji Uchida
Aug 14, 2020·International Journal of Clinical Oncology·Ryo OhtaHideyuki Ishida
Aug 6, 2021·Toxicology·Chen ZhuChengliang Zhang
Sep 16, 2021·Histochemistry and Cell Biology·Eddie WisseGer Koek
Oct 11, 2017·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T ChapelleS Francque

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