Hepatic steatosis in liver transplant donors: rare phenomenon or common feature of donor population?

Transplantation Proceedings
A HałońJ Rabczyński

Abstract

The aim of this research was a histopathological assessment of cadaveric donor liver steatosis including: the degree (percent of involved hepatocytes) and type size of vacuoles showing fatty change by various histologic techniques. The study included 70 donor livers. Hematoxylin-eosin and Sudan III staining methods were used for the examination. The degree of steatosis was assessed according to the Dixon scale with the type of fatty degeneration classified into three steatotic patterns. Steatosis was observed in 36/70 donor livers (51.4%) including those from 23 male (64%) and 13 female (36%) patients. The mean age of the steatotic donors was 53.7 years in contrast to the nonsteatotic donors of 45.3 years. Mild steatosis was identified in five of all sections (7.1%); mild focal and moderate zonal steatosis in 10 (14.3%), and severe, panlobular steatosis in 11 (15.3%). Fatty liver was observed as the only microscopic feature in nine cases (13%), in combination with cholestasis in 2 (2.8%); with inflammation in 5 (7%); and together with inflammation, fibrosis, and cholestasis in 20 (29%). Three types of steatotic pattern were shown: (1) small-droplet lipid vacuolization (microsteatosis) in 7/36 cases (19%); (2) large and small fa...Continue Reading

References

Jan 1, 1996·Journal of Hepatology·F TrevisaniD H Van Thiel
Jul 23, 1998·World Journal of Surgery·M A Garcia UreñaR Gómez Sanz
Nov 9, 2000·Human Pathology·H CrowleyU Khettry
May 11, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Charles J ImberPeter J Friend
May 13, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Deborah VerranGeoffery McCaughan
Apr 30, 2004·Human Pathology·Hendrik MarsmanScott L Nyberg
Jun 15, 2004·Transplantation Proceedings·R C AfonsoB H Ferraz-Neto

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Citations

May 26, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jan P DerooseIan P J Alwayn
May 22, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Magdy AttiaDarius F Mirza
Sep 3, 2013·Clinical Transplantation·Kenneth D ChavinPrabhakar K Baliga
Apr 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Q ChengK Man
Jan 30, 2015·Alimentary Pharmacology & Therapeutics·E C Verna, R Loomba
Jan 6, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Daniel J EversTheo J M Ruers
Aug 16, 2011·Transplantation Proceedings·K FukumitsuA Soto-Gutierrez
Nov 27, 2009·Orvosi hetilap·Balázs NemesLászló Kóbori
Jun 18, 2011·Transplantation·Russell W JamiesonPeter J Friend
Nov 13, 2018·Transplantation·Ivan LinaresMarkus Selzner
Nov 5, 2010·Physics in Medicine and Biology·B L McLaughlinP A Robertson
Dec 10, 2019·Transplantation·Kyle R JacksonJacqueline Garonzik-Wang
Aug 20, 2016·International Journal of Environmental Health Research·Joseane Balan Da SilvaMax Jean Ornelas Toledo
May 27, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Natalie M BathDavid P Foley
Aug 1, 2020·Transplantation·Kyle R JacksonJacqueline Garonzik-Wang
Aug 23, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ahad EshraghianSeyed Ali Malek-Hosseini

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