Hepatic steatosis in patients with HIV-Hepatitis C Virus coinfection: is it associated with antiretroviral therapy and more advanced hepatic fibrosis?

BMC Research Notes
Sumita VermaJanice Main

Abstract

Patients with HIV and hepatitis C virus (HCV) coinfection are at increased risk of developing hepatic steatosis. The aims of this study were to assess the prevalence of steatosis in a cohort with HIV-HCV coinfection, and to determine an association, if any, between steatosis, antiretroviral therapy (ART), and advanced hepatic fibrosis. HIV-HCV coinfected patients were retrospectively identified from the HIV clinic. ART was classified as none, nucleoside reverse transcriptase inhibitors (NRTIs) only, highly active antiretroviral therapy (HAART) only, and sequential therapy (initial NRTIs followed by HAART). Fibrosis stage and necroinflammation grade were assessed by the modified HAI (Ishak) scoring method. Steatosis was graded as 0-3. Sixty patients were identified. The overall prevalence of hepatic steatosis was 58%. Those that received HAART only had a lower prevalence of steatosis (41%) compared to those on NRTIs only (70%) or sequential therapy (82%). Independent predictors of hepatic steatosis were absence of HAART only therapy, OR 2.9, p = 0.09, and presence of cirrhosis, OR 4.6, p = 0.044. Forty five percent of the patients had advanced fibrosis (fibrosis stage >/= 3). NI grade (OR 1.9, p = 0.030), and steatosis grade (OR...Continue Reading

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Citations

Jun 25, 2014·Indian Journal of Sexually Transmitted Diseases and AIDS·Deepika Pandhi, Pallavi Ailawadi
Jun 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mariana Verdelho MachadoHelena Cortez-Pinto
Oct 21, 2015·Infection & chemotherapy·UNKNOWN Korean Society for AIDS
Jan 30, 2014·Infection & chemotherapy·UNKNOWN Korean Society for AIDS
Aug 13, 2009·World Journal of Gastroenterology : WJG·Ashwani-K Singal, Bhupinderjit S Anand
Apr 4, 2019·Infection & chemotherapy·UNKNOWN Korean Society for AIDS

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