Abstract
In this study, we evaluated whether hepatic steatosis affects the viral response to interferon (IFN) and ribavirin combination therapy in Japanese patients with chronic hepatitis C (CHC). Eighty CHC patients treated with IFN alpha-2b and ribavirin for 24 weeks were evaluated retrospectively. Liver biopsy specimens were assessed histopathologically, and grade of steatosis was scored as follows: grade 0: <5%; grade 1: 5-33%; grade 2: 33-66%; grade 3: >66%. Sustained viral response (SVR) was defined as negative for HCV-RNA by high-sensitivity qualitative reverse transcription-polymerase chain reaction (RT-PCR) at 24 weeks post-treatment. Hepatic steatosis graded 2 and higher was seen in 28.8% patients, whose average BMI were significantly higher than those in grade 0 patients. Grade of steatosis was well correlated with elevation in serum aminotransferases and gamma-glutamyltranspeptidase (gamma-GTP) levels, but not with histological degree of inflammation and fibrosis. The SVR rates were significantly lower in the group with overt steatosis (grade 2/3) as compared to the group with less steatosis (grade 0/1), the values being 30.4% and 57.9%, respectively. Moreover, grade of steatosis was selected as an independent negative facto...Continue Reading
Citations
May 12, 2012·Gastroenterology Research and Practice·Savvidou SavvoulaGoulis John
Aug 20, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Maribel Rodriguez-TorresMitchell Shiffman
Jun 2, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Soo R Kim
Jun 2, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hideyuki NomuraHiromi Ishibashi
Sep 18, 2016·Journal of Gastroenterology·Wai-Kay Seto, Man-Fung Yuen
Mar 24, 2009·AJR. American Journal of Roentgenology·Muriel WebbRan Oren
Oct 10, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Suk SeoNatalie Torok
Nov 13, 2007·Digestive Diseases and Sciences·Manuela G NeumanGiuliano Ramadori
Feb 26, 2008·Journal of Medical Virology·Rinaldo PellicanoMario Rizzetto
Jan 15, 2008·The American Journal of Gastroenterology·Theodoros A ZografosGeorge N Dalekos
Jul 24, 2008·Journal of Gastroenterology·Sumio WatanabeAkihisa Miyazaki
Oct 1, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Sumio WatanabeUNKNOWN PERFECT Study Group
Nov 23, 2006·Internal and Emergency Medicine·Nicola Carulli
Nov 3, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hisamitsu MiyaakiKazuhiko Nakao
Sep 11, 2010·Journal of Gastroenterology·Masayuki KurosakiNamiki Izumi
Mar 26, 2008·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Kenichi IkejimaSumio Watanabe
Jan 14, 2017·PloS One·Cordelia ManickamR Keith Reeves
Mar 4, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Aleksandra Berkan-KawińskaRobert Flisiak
Jun 5, 2007·Clinics in Liver Disease·Eve A Roberts