Hepatic steatosis progresses faster in HIV mono-infected than HIV/HCV co-infected patients and is associated with liver fibrosis

Journal of Hepatology
Thomas PembrokeGiada Sebastiani

Abstract

Hepatic steatosis (HS) seems common in patients infected with human immunodeficiency virus (HIV). However, the relative effect of HIV, as well as hepatitis C virus (HCV) in those co-infected, and the influence of HS on liver fibrosis progression are unclear. The LIVEr disease in HIV (LIVEHIV) is a Canadian prospective cohort study using transient elastography and associated controlled attenuation parameter (CAP) to screen for HS and liver fibrosis, in unselected HIV-infected adults. HS progression was defined as development of any grade HS (CAP ⩾248dB/m), or transition to severe HS (CAP >292dB/m), for those with any grade HS at baseline. Fibrosis progression was defined as development of significant liver fibrosis (liver stiffness measurement [LSM] >7.1kPa), or transition to cirrhosis (LSM >12.5kPa) for those with significant liver fibrosis at baseline. Cox regression analysis was used to assess predictors of HS and fibrosis progression. A prospective cohort study was conducted, which included 726 HIV-infected patients (22.7% HCV co-infected). Prevalence of any grade HS did not differ between HIV mono-infected and HIV/HCV co-infected patients (36.1% vs. 38.6%, respectively). 313 patients were followed for a median of 15.4 (inte...Continue Reading

References

Sep 18, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Salvatore PettaVictor de Ledinghen
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Citations

May 9, 2018·Expert Review of Anti-infective Therapy·Fabienne MarcellinMaria Patrizia Carrieri
Dec 21, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Laura Iogna PratEmmanuel Tsochatzis
Mar 25, 2019·Expert Review of Gastroenterology & Hepatology·Carlos Esteban Coronel-CastilloNahum Méndez-Sánchez
Apr 16, 2019·The American Journal of Gastroenterology·Arthur Y Kim
May 14, 2019·Expert Review of Gastroenterology & Hepatology·Nicola SquillaceAlessandra Bandera
Dec 19, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Amine BenmassaoudGiada Sebastiani
Sep 21, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas Krahn, Giada Sebastiani
Dec 10, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicolás MerchanteGiada Sebastiani
Feb 14, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni GuaraldiUNKNOWN SHIVER Network
May 20, 2020·Scientific Reports·Marina Ferri PezziniJulia Poeta
Apr 14, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adriana CervoGiada Sebastiani
Feb 16, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cai Jia, Giada Sebastiani
Sep 29, 2020·Current HIV/AIDS Reports·Adriana CervoGiada Sebastiani
Mar 11, 2019·The Journal of Infectious Diseases·Julia A AepfelbacherColleen Hadigan
Apr 10, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jia Cai, Giada Sebastiani
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Mar 7, 2021·Seminars in Immunology·Catherine W Cai, Irini Sereti

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