Hepatic stellate cells as key target in liver fibrosis

Advanced Drug Delivery Reviews
Takaaki HigashiYujin Hoshida

Abstract

Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more than one million deaths annually via development of cirrhosis, although no antifibrotic therapy has been approved to date. Transdifferentiation (or "activation") of hepatic stellate cells is the major cellular source of matrix protein-secreting myofibroblasts, the major driver of liver fibrogenesis. Paracrine signals from injured epithelial cells, fibrotic tissue microenvironment, immune and systemic metabolic dysregulation, enteric dysbiosis, and hepatitis viral products can directly or indirectly induce stellate cell activation. Dysregulated intracellular signaling, epigenetic changes, and cellular stress response represent candidate targets to deactivate stellate cells by inducing reversion to inactivated state, cellular senescence, apoptosis, and/or clearance by immune cells. Cell type- and target-specific pharmacological intervention to therapeutically induce the deactivation will enable more effective and less toxic precision antifibrotic therapies.

References

Jul 1, 1985·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R BorojevicJ A Grimaud
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·N SandersonS S Thorgeirsson
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J SchnurS S Thorgeirsson
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patricia F LalorDavid H Adams
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bernd SchnablDavid Brenner
Jun 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zsuzsa SzondyLaszlo Fesus
Sep 5, 2003·Cell Transplantation·Norikuni ShibataNaoya Kobayashi
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fausto AndreolaLuigi M De Luca
Nov 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ewa WandziochLeif Carlsson
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jean S CampbellNelson Fausto
Jun 9, 2005·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Jee-Soo Kim, Shivendra D Shukla
Jul 7, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Marie FukushimaHajime Nawata
Nov 9, 2005·The Journal of Clinical Investigation·Tatiana I NovobrantsevaAlexander Ibraghimov
Jan 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Akira AnanGregory J Gores
Jul 18, 2006·Journal of Hepatology·Piotr CzochraStephan Kanzler
Jul 19, 2006·Journal of Hepatology·Tatiana KisselevaDavid A Brenner
Sep 9, 2006·Journal of Gastroenterology and Hepatology·Hidekazu TsukamotoTakeo Miyahara
Oct 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Steve S ChoiAnna Mae Diehl
May 9, 2007·Gastroenterology·Samuele De MinicisRobert F Schwabe
Aug 21, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Azuma WatanabeWajahat Zafar Mehal
Oct 16, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sònia TuguesManuel Morales-Ruiz
Oct 24, 2007·Nature Medicine·Ekihiro SekiRobert F Schwabe
Nov 17, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jason H ChengHidekazu Tsukamoto
Dec 27, 2007·Biochemical and Biophysical Research Communications·Claus KordesDieter Häussinger
Mar 1, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rebecca G Wells
Apr 10, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Shigeo HisamoriYoshiharu Sakai
Aug 30, 2008·Cell·Valery KrizhanovskyScott W Lowe
Oct 11, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Muhammad A SohailWajahat Z Mehal
Dec 17, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jinsheng GuoScott L Friedman
Jan 7, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kojiro TauraDavid A Brenner
Mar 9, 2010·Gastroenterology·Takahiro KodamaNorio Hayashi
Mar 17, 2010·Molecular and Cellular Endocrinology·Yajun ZhouXiaoliang Sun

❮ Previous
Next ❯

Citations

Feb 10, 2018·Cancers·Patrizia BurraGiacomo Germani
Apr 17, 2018·Nutrients·Jeremy T KeaneJenny E Gunton
Mar 15, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chen QuJian Hong
Sep 18, 2018·Annals of the New York Academy of Sciences·Sai Krishna Athuluri-Divakar, Yujin Hoshida
Dec 7, 2018·International Journal of Molecular Sciences·Stefania CannitoMassimiliano Cadamuro
Dec 19, 2018·Basic & Clinical Pharmacology & Toxicology·Sael Casas-GrajalesPablo Muriel
Sep 20, 2018·Annual Review of Pathology·Jingjing CaiHongliang Li
Jul 10, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Alexandre BalaphasLeo Hans Bühler
Jun 18, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Justin D SchumacherGrace L Guo
Sep 10, 2019·Cell Biology International·Feng ZhangYuzheng Zhuge
Sep 8, 2019·Cells·Andrey V ElchaninovGennady T Sukhikh
Nov 5, 2019·Journal of Cellular Biochemistry·Rui FengYanqing Liu
Nov 7, 2019·Expert Review of Gastroenterology & Hepatology·Rosanna Santoro, Alessandra Mangia
Oct 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yunyang BaoDanqing Song
Nov 30, 2019·Science Translational Medicine·Neeta B AminBryan Goodwin
Feb 16, 2020·Journal of Biochemical and Molecular Toxicology·Durgesh K DwivediVinod Kumar
Mar 25, 2020·Cell Biochemistry and Function·Ewa MatuszczakAdam Hermanowicz
Apr 2, 2020·Cells·Alejandra HernándezMarco Arrese
May 5, 2020·Journal of Gastroenterology and Hepatology·Tomoki KobayashiSusumu Tazuma
Apr 24, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Naoto FujiwaraYujin Hoshida
Apr 20, 2020·European Journal of Clinical Investigation·Zhiheng DongAgula Bo
May 7, 2020·American Journal of Physiology. Cell Physiology·Xinghui Sun, Edward N Harris
Jun 13, 2020·Human Vaccines & Immunotherapeutics·Anissa A WidjajaStuart A Cook
Jul 10, 2020·Journal of Cellular and Molecular Medicine·Xiaohe LiCheng Yang
Jul 16, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Joseph GeorgeMikihiro Tsutsumi
Aug 15, 2020·Experimental Biology and Medicine·Devaraj Ezhilarasan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Related Papers

Annual Review of Pathology
Virginia Hernandez-Gea, Scott L Friedman
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
G CarpinoE Gaudio
Gastroentérologie Clinique Et Biologique
J F BlancJ Rosenbaum
© 2022 Meta ULC. All rights reserved