Hepatic stellate cells in inflammation-fibrosis-carcinoma axis

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Bin-Bin WangHuijie Bian

Abstract

Almost 80% of hepatocellular carcinoma (HCC) cases are associated with chronic hepatitis and cirrhosis resulting from inflammation and fibrosis. A three-step process of "inflammation-fibrosis-carcinoma" is believed to be involved in hepatocarcinogenesis. The activation of hepatic stellate cells (HSCs) may serve as an important mediator in the process of inflammation-fibrosis-carcinoma axis, even in tumor metastasis. A remarkable knowledge of activated HSCs in the pathology of HCC development is mostly focused on the liver fibrosis. The molecular links that connects inflammation and cancer in the activation of HSC are not completely known. This highlights urgent need to increase our understanding of the cellular and molecular mechanisms, by which activation of HSCs is involved in the hepatic inflammation, carcinogenesis, and metastasis.

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Citations

Mar 14, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Haitao ShiXiaoyan Guo
May 9, 2015·International Journal of Inflammation·Florent DuvalDelia Elva Cruz-Vega
Jun 14, 2016·Alcoholism, Clinical and Experimental Research·Elizabeth Brandon-WarnerLaura W Schrum
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Sep 28, 2018·Food & Function·Nisha Susan ThomasAthavan Alias Anand Selvam
Jun 22, 2019·BMC Complementary and Alternative Medicine·Li-Ying SongShi-Kun Liu
Sep 21, 2017·BioMed Research International·Li-Ying SongShi-Kun Liu
Oct 28, 2019·Parasitology Research·Asmaa R EllakanyAmira E Abdel Ghaffar

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